Testing Data
Ki8751, inhibitor
Ki8751
Synonyms
Ki8751; inhibitor
Solubility
DMSO >=94 mg/mL - Water <1 mg/mL - Ethanol <1 mg/mL
Formula
C24H18F3N3O4
CAS Number
228559-41-9
Preparation and Storage
Stable for; 2 years at -20 degree C Powder
1 week -4 degree C in DMSO
1 month -80 degree C in DMSO
1 week -4 degree C in DMSO
1 month -80 degree C in DMSO
Testing Data
Testing Data
Related Product Information for Ki8751, inhibitor
Ki8751 is a potent, selective VEGFR-2 tyrosine kinase inhibitor with IC50 of 0.9, 40, 67, 170 nM for VEGF-2, c-Kit, PDGFRalpha and FGFR-2, respectively. It exhibited no effect against eight other commonly studied receptor and non-receptor kinases even at concentrations as high as 10 uM. It is highly selective over other receptor tyrosine kinases (IC50 > 10000 nM for EGFR and HGFR). It inhibits VEGF-stimulated proliferation of human umbilical vein endothelial cells (HUVEC) and inhibits tumor growth in vivo. [1][2]
Product Categories/Family for Ki8751, inhibitor
References
Novel Potent Orally Active Selective VEGFR-2 Tyrosine Kinase Inhibitors:Synthesis, Structure Activity Relationships, and Antitumor Activities of N-Phenyl-N?-{4-(4-quinolyloxy)phenyl}ureas Toshiyuki Shimizu, Shin-ichi Ohyama, et al. J. Med. Chem 2005; 48:1359-1366 Potential Role of Follicle-Stimulating Hormone (FSH) and Transforming Growth Factor (TGFb1) in the Regulation of Ovarian Angiogenesis SHIH-WEI KUO, FERNG-CHUN KE, et al. J. Cell. Physiol 2011; 226: 1608-1619 The pharmacological and toxicological properties of this product have not been fully investigated. Exercise caution in use and handling. This product must not be used in humans.
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Product Notes
The Ki8751 (Catalog #AAA8506470) is an Inhibitor and is intended for research purposes only. The product is available for immediate purchase. It is sometimes possible for the material contained within the vial of "Ki8751, Inhibitor" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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