Testing Data
Roscovitine, Inhibitor
Roscovitine (Seliciclib)
Purity
>99%
Synonyms
Roscovitine; Roscovitine (Seliciclib); inhibitor
Purity/Purification
>99%
Solubility
DMSO >=71mg/mL - Water <1mg/mL - Ethanol >=71mg/mL
Formula
C19H26N6O
CAS Number
186692-46-6
Preparation and Storage
Store at-20 degree C 2 years.
Testing Data
Testing Data
Related Product Information for Roscovitine, inhibitor
Roscovitine (Seliciclib, CYC202) is a potent and selective inhibitor of cyclin-dependent kinases (cdks). This agent displays higher inhibitory potency and higher selectivity compared to olomoucine. [1] Roscovitine (Seliciclib, CYC202) inhibits p34 cdc2/cyclin B (IC50 = 0.65 uM), p33 cdk2/cyclin A(IC50 = 0.70 uM), p33 cdk2/cyclin E (IC50 = 0.70 uM), and p33 cdk2/p35(IC50 = 0.20 uM) by competing for the ATP binding domain of these kinases. Roscovitine (Seliciclib, CYC202) exhibits very low sensitivity towards related kinases, such as erk1 and erk2 (IC50 = 34 uM and 14 uM, respectively).[2] Roscovitine (Seliciclib, CYC202) doesnot significantly affect the activity of other protein kinases even at 100 uM and compared to olomoucine. Roscovitine displays increased anti-mitotic activity at the G1/S and G2/M phases of the cell cycle. [3]
Product Categories/Family for Roscovitine, inhibitor
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Product Notes
The Roscovitine (Catalog #AAA8506225) is an Inhibitor and is intended for research purposes only. The product is available for immediate purchase. It is sometimes possible for the material contained within the vial of "Roscovitine, Inhibitor" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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