Western Blot (WB)
(Western Blot: Sample: Human HepG2 cell lysatePrimary Ab: 3ug/ml Mouse Anti-Human C1INH AntibodySecond Ab 0.2ug/mL HRP-Linked Caprine Anti-Mouse IgG Polyclonal Antibody (Catalog: MBS2086035 ))
Mouse Complement 1 Inhibitor (C1INH) Monoclonal Antibody | anti-C1INH antibody
Monoclonal Antibody to Complement 1 Inhibitor (C1INH)
Immunohistochemistry: 5-50ug/mL
Immunocytochemistry: 5-50ug/mL
Optimal working dilutions must be determined by end user.
Avoid repeated freeze/thaw cycles.
Store at 4 degree C for frequent use.
Aliquot and store at -20 degree C for 24 months.
Stability Test:
thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37 degree C for 48h, and no obvious degradation and precipitation were observed. The loss rate is less than 5% within the expiration date under appropriate storage condition.
Western Blot (WB)
(Western Blot: Sample: Human HepG2 cell lysatePrimary Ab: 3ug/ml Mouse Anti-Human C1INH AntibodySecond Ab 0.2ug/mL HRP-Linked Caprine Anti-Mouse IgG Polyclonal Antibody (Catalog: MBS2086035 ))
Western Blot (WB)
(Western Blot: Sample: Human HepG2 cell lysatePrimary Ab: 3ug/ml Mouse Anti-Human C1INH AntibodySecond Ab 0.2ug/mL HRP-Linked Caprine Anti-Mouse IgG Polyclonal Antibody (Catalog: MBS2086035 ))
Western Blot (WB)
(Western Blot: Sample: Recombinant C1INH, Human.)
Western Blot (WB)
(Western Blot: Sample: Recombinant C1INH, Human.)
Immunohistochemistry (IHC)
(DAB staining on IHC-P; Samples: Human Liver Tissue; Primary Ab: 40µg/ml Mouse Anti-Human C1INH Antibody Second Ab: 2µg/mL HRP-Linked Caprine Anti-Mouse IgG Polyclonal Antibody (Catalog: MBS2086035 ))
Immunohistochemistry (IHC)
(DAB staining on IHC-P; Samples: Human Liver Tissue; Primary Ab: 40µg/ml Mouse Anti-Human C1INH Antibody Second Ab: 2µg/mL HRP-Linked Caprine Anti-Mouse IgG Polyclonal Antibody (Catalog: MBS2086035 ))
NCBI and Uniprot Product Information
NCBI Description
This gene encodes a highly glycosylated plasma protein involved in the regulation of the complement cascade. Its protein inhibits activated C1r and C1s of the first complement component and thus regulates complement activation. Deficiency of this protein is associated with hereditary angioneurotic oedema (HANE). Alternative splicing results in multiple transcript variants encoding the same isoform. [provided by RefSeq, Jul 2008]
Uniprot Description
SERPING1: a protein protease inhibitor (C1-inhibitor) that forms a proteolytically inactive stoichiometric complex with the C1r or C1s proteases. May play an important role in regulating complement activation, blood coagulation, fibrinolysis and the generation of kinins. Very efficient inhibitor of FXIIa. Mutations of the SERPING1 gene is associated with adult macular degeneration can also cause hereditary angioedema. Binds to E.coli stcE which allows localization of SERPING1 to cell membranes thus protecting the bacteria against complement-mediated lysis. Belongs to the serpin family.
Protein type: Secreted; Secreted, signal peptide
Chromosomal Location of Human Ortholog: 11q12.1
Cellular Component: extracellular region; extracellular space
Molecular Function: protein binding; serine-type endopeptidase inhibitor activity
Biological Process: aging; blood circulation; blood coagulation, intrinsic pathway; complement activation, classical pathway; fibrinolysis; innate immune response; negative regulation of complement activation, lectin pathway; platelet degranulation; regulation of complement activation
Disease: Angioedema, Hereditary, Type I; Complement Component 4, Partial Deficiency Of
Research Articles on C1INH
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Product Notes
The C1INH serping1 (Catalog #AAA2012604) is an Antibody produced from Mouse and is intended for research purposes only. The product is available for immediate purchase. The Monoclonal Antibody to Complement 1 Inhibitor (C1INH) reacts with Homo sapiens (Human) and may cross-react with other species as described in the data sheet. AAA Biotech's Complement 1 Inhibitor (C1INH) can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB); Immunohystochemistry (IHC); Immunocytochemistry (ICC); Immunoprecipitation (IP). Western blotting: 0.5-5ug/mL Immunohistochemistry: 5-50ug/mL Immunocytochemistry: 5-50ug/mL Optimal working dilutions must be determined by end user. Researchers should empirically determine the suitability of the C1INH serping1 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "Complement 1 Inhibitor (C1INH), Monoclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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