Testing Data
ZM-447439, inhibitor
ZM-447439
Purity
>99%
Synonyms
ZM-447439; inhibitor
Purity/Purification
>99%
Solubility
DMSO >=103mg/mL - Water <1mg/mL - Ethanol >=48mg/mL
Formula
C29H31N5O4
CAS Number
331771-20-1
Preparation and Storage
Store at-20 degree C 2 years.
Testing Data
Testing Data
Related Product Information for ZM-447439, inhibitor
ZM-447439 is a potent and selective Aurora B kinase inhibitor with an IC50 of 50 nM, 1 muM and 250 nM for Aurora B, A and C, respectively. Other kinases such as Cdk1 and PLK1 are not inhibited (up to 10 mM). Cells treated with ZM-447439 progress through interphase, enter mitosis and assemble bipolar spindles but chromosome alignment, segregation and cytokinesis all fail. Mitotic Aurora kinases are essential for accurate chromosome segregation during cell division. Forced overexpression of Aurora kinase results in centrosome amplification and multipolar spindles, causing aneuploidy, a hallmark of cancer. ZM447439 does not interfere with other kinases when used up to 5 uM. ZM447439 dose-dependently inhibited proliferation of all three cell lines (BON, QGP-1 and MIP-101) with IC50 values in the nanomolar to low micromolar range. Moreover, aurora kinase inhibition by ZM447439 potently induced apoptosis, which was accompanied by DNA fragmentation and caspase 3 and 7 activation. [1][2][3]
Product Categories/Family for ZM-447439, inhibitor
References
ZM 447439 inhibition of aurora kinase induces Hep2 cancer cell apoptosis in three-dimensional culture Zi-Jie Long, Jie Xu, et al. Cell Cycle 15 May 2008; 7:10, 1473-1479 Aurora B couples chromosome alignment with anaphase by targeting BubR1, Mad2, and Cenp-E to kinetochores Claire Ditch?eld, Victoria L. Johnson, et al. The Journal of Cell Biology 2003; 161:267-280 Discovery of Novel and Potent Thiazoloquinazolines as Selective Aurora A and B Kinase Inhibitors Georges Pasquet, Christine Lambert-van der Brempt, et al. J. Med. Chem 2006; 49:955-970. The pharmacological and toxicological properties of this product have not been fully investigated. Exercise caution in use and handling. This product must not be used in humans.
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Product Notes
The ZM-447439 (Catalog #AAA8506521) is an Inhibitor and is intended for research purposes only. The product is available for immediate purchase. It is sometimes possible for the material contained within the vial of "ZM-447439, Inhibitor" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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