Molecular Structure
A83-01, inhibitor
A83-01
Purity
>98% (TLC); NMR (Conforms)
Synonyms
A83-01; AR-A014418 ; N-[(4-Methoxyphenyl) methyl]-N'-(5-nitro-2-thiazolyl)urea; 3-(6-Methyl-2-pyridinyl)-N-phenyl-4-(4-quinolinyl)-1H-pyrazole-1-carbothioamide; inhibitor
Purity/Purification
>98% (TLC); NMR (Conforms)
Form/Format
Light Yellow powder
CAS Number
909910-43-6
Molecular Formula
C25H19N5S
Activity
GSK3b inhibitor
Reconstitution
May be dissolved in DMSO (30mg/ml)
Solubilization
May be dissolved in DMSO (20mg/ml)
Preparation and Storage
Store desiccated as supplied at -20 degree C for up to 2 years. Store solutions at -20 degree C for up to 2 months.
Molecular Structure
Molecular Structure
Related Product Information for A83-01, inhibitor
ALK inhibitor
Selective glycogen synthase kinase 3 (GSK-3) inhibitor (IC50=104 nM). Inhibits -amyloid-mediated neurodegeneration in hippocampal slices. Antiinflammatory activity. Cell permeable. Active in rodent models.
Scientific Background: Potent and selective ALK4, 5 and 7 inhibitor (1,2). IC50=45, 12, 7.5 nM respectively. Prevents phosphorylation of Smad2/3 and growth inhibition induced by TGFbeta (2). Inhibits differentiation of rat induced pluripotent stem cells and increases clonal expansion efficiency (3). Together with AMI-5 enabled Oct4-induced reprogramming of mouse embryonic fibroblasts (4). Active in rat models. Cell permeable
Selective glycogen synthase kinase 3 (GSK-3) inhibitor (IC50=104 nM). Inhibits -amyloid-mediated neurodegeneration in hippocampal slices. Antiinflammatory activity. Cell permeable. Active in rodent models.
Scientific Background: Potent and selective ALK4, 5 and 7 inhibitor (1,2). IC50=45, 12, 7.5 nM respectively. Prevents phosphorylation of Smad2/3 and growth inhibition induced by TGFbeta (2). Inhibits differentiation of rat induced pluripotent stem cells and increases clonal expansion efficiency (3). Together with AMI-5 enabled Oct4-induced reprogramming of mouse embryonic fibroblasts (4). Active in rat models. Cell permeable
Product Categories/Family for A83-01, inhibitor
References
R Bhat et al. J. Biol. Chem. 2003 278: 45937
SH Ramirez et al. Am. J. Pathol. 2010 176:881
SH Ramirez et al. Am. J. Pathol. 2010 176:881
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Product Notes
The A83-01 (Catalog #AAA515040) is an Inhibitor and is intended for research purposes only. The product is available for immediate purchase. It is sometimes possible for the material contained within the vial of "A83-01, Inhibitor" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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