Molecular Structure
MLS-573151, inhibitor
MLS-573151
Purity
>99% (TLC); NMR (Conforms)
Synonyms
MLS-573151; AICAR; 5-Aminoimidazole-4-carboxamide 1-beta-D-ribofuranoside; Acadesine; 4-[3; 5-diphenyl-4; 5-dihydropyrazol-1-yl] benzenesulfonamide; inhibitor
Purity/Purification
>99% (TLC); NMR (Conforms)
Form/Format
Yellow powder
CAS Number
2627-69-2
Molecular Formula
C21H19N3O2S
Melting Point
213-214 degree C (dec.)
Activity
AMPK activator
Reconstitution
Soluble in DMSO (15 mg/ml); or water (15 mg/ml)
Solubilization
May be dissolved in DMSO (20 mg/ml)
Preparation and Storage
Store desiccated as supplied at room temperature for up to 2 years. Store solutions at -20 degree C for up to 2 months.
Molecular Structure
Molecular Structure
Related Product Information for MLS-573151, inhibitor
Cdc-42 inhibitor
Activates AMP-activated protein kinase (AMPK). Promotes ligand-independent activation of the insulin receptor1. Promotes skeletal muscle autophagy via activation of FoxO3a2. Controls smooth muscle cell hyperproliferation in vascular disease3. Cell permeable.
Scientific Background: MLS-573151 is a potent and specific inhibitor of Cdc42 a small GTPase of the Rho-subfamily (IC50=2 uM).
Activates AMP-activated protein kinase (AMPK). Promotes ligand-independent activation of the insulin receptor1. Promotes skeletal muscle autophagy via activation of FoxO3a2. Controls smooth muscle cell hyperproliferation in vascular disease3. Cell permeable.
Scientific Background: MLS-573151 is a potent and specific inhibitor of Cdc42 a small GTPase of the Rho-subfamily (IC50=2 uM).
Product Categories/Family for MLS-573151, inhibitor
References
1. I Chopra et al. Diabetologia 2012 55:783
2. AM Sanchez et al. J. Cell Biochem. 2012 113:695
3. N Ferri et al. Vascul. Pharmacol. 2012 56:9
2. AM Sanchez et al. J. Cell Biochem. 2012 113:695
3. N Ferri et al. Vascul. Pharmacol. 2012 56:9
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Product Notes
The MLS-573151 (Catalog #AAA515010) is an Inhibitor and is intended for research purposes only. The product is available for immediate purchase. It is sometimes possible for the material contained within the vial of "MLS-573151, Inhibitor" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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