Molecular Structure
DPMQ 2 HCl, inhibitor
DPMQ 2 HCl
Purity
99% (TLC); NMR (Conforms)
Synonyms
DPMQ 2 HCl; CHIR-99021; 6-[[2-[[4-(2; 4-Dichlorophenyl)-5-(5-methyl-1H-imidazol-2-yl)-2-pyrimidinyl]amino]ethyl]amino]-3-pyridinecarbonitrile; 5; 7-Dimethoxy-3-(4-pyridinyl) quinoline dihydrochloride; inhibitor
Purity/Purification
99% (TLC); NMR (Conforms)
Form/Format
Yellow powder
CAS Number
137206-97-4
Molecular Formula
C16H14N2O2 -2HCl
Melting Point
231-234 degree C
Activity
GSK3b inhibitor
Reconstitution
May be dissolved in DMSO (25 mg/ml, warm)
Solubilization
May be dissolved in Water (30 mg/ml) or DMSO (1 mg/ml, warm)
Preparation and Storage
Store desiccated as supplied at room temperature for up to 2 years. Store solutions at -20 degree C for up to 3 months.
Molecular Structure
Molecular Structure
Related Product Information for DPMQ 2 HCl, inhibitor
PDGFRbeta inhibitor
Potent and selective inhibitor of glycogen synthase kinase-3beta (GSK3beta, IC50 = 5 nM) and GSK3alpha (IC50 = 10 nM)1. Induces osteoblastogenesis, increases mineralization and inhibits adipogenesis in ST2 cells2. Promotes replication and survival of pancreatic beta cells3. Enhances differentiation and reduces proliferation of adult human olfactory epithelium neural precursors4. Cell permeable and active in vivo.
Scientific Background: A potent and selective inhibitor of PDGFRbeta, IC50=80 nM. Greater than 100-fold more selective compared to EGFR, erB2, p56, PKA and PKC. Cell permeable.
Potent and selective inhibitor of glycogen synthase kinase-3beta (GSK3beta, IC50 = 5 nM) and GSK3alpha (IC50 = 10 nM)1. Induces osteoblastogenesis, increases mineralization and inhibits adipogenesis in ST2 cells2. Promotes replication and survival of pancreatic beta cells3. Enhances differentiation and reduces proliferation of adult human olfactory epithelium neural precursors4. Cell permeable and active in vivo.
Scientific Background: A potent and selective inhibitor of PDGFRbeta, IC50=80 nM. Greater than 100-fold more selective compared to EGFR, erB2, p56, PKA and PKC. Cell permeable.
Product Categories/Family for DPMQ 2 HCl, inhibitor
References
1. CN Bennett et al. J. Biol. Chem. 2002 277:30998
2. CN Bennett et al. PNAS 2005 102:3324
3. R Mussmann et al. J. Biol. Chem. 2007 282:12030
4. AP Manceur et al. Exp. Cell. Res. 2011 317:2086
2. CN Bennett et al. PNAS 2005 102:3324
3. R Mussmann et al. J. Biol. Chem. 2007 282:12030
4. AP Manceur et al. Exp. Cell. Res. 2011 317:2086
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Product Notes
The DPMQ 2 HCl (Catalog #AAA515080) is an Inhibitor and is intended for research purposes only. The product is available for immediate purchase. It is sometimes possible for the material contained within the vial of "DPMQ 2 HCl, Inhibitor" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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