Molecular Structure
SB-202190, inhibitor
SB-202190
Purity
>98% (TLC: 10% CH3OH in CH2Cl2, Rf=0.25); NMR (Conforms)
Synonyms
SB-202190; NVP-BEZ235; 4-[4-(4-Fluorophenyl)-5-(4-pyridinyl)-1H-imidazol-2-yl] phenol; inhibitor
Purity/Purification
>98% (TLC: 10% CH3OH in CH2Cl2, Rf=0.25); NMR (Conforms)
Form/Format
Yellow powder
CAS Number
152121-30-7
Molecular Formula
C20H14N3OF
Melting Point
277-278 degree C
Activity
PI3-K and mTOR inhibitor
Solubilization
May be dissolved in DMSO (30mg/ml)
Preparation and Storage
Store desiccated as supplied at -20 degree C for up to 2 years. Store solutions at -20 degree C for up to 2 months.
Molecular Structure
Molecular Structure
Related Product Information for SB-202190, inhibitor
p38 MAP kinase inhibitor
Scientific Background: Potent and selective p38 MAP kinase inhibitor acting at the ATP site (1). Selectively inhibits the p38alpha and beta isoforms (IC50= 50 and 100 nM for SAPK2a/p38 and SAPK2b/p38beta2 respectively) (2). Effectively blocks LPS-induced gene expression in monocytes (3). Induces apoptosis (4). Cell permeable.
Scientific Background: Potent and selective p38 MAP kinase inhibitor acting at the ATP site (1). Selectively inhibits the p38alpha and beta isoforms (IC50= 50 and 100 nM for SAPK2a/p38 and SAPK2b/p38beta2 respectively) (2). Effectively blocks LPS-induced gene expression in monocytes (3). Induces apoptosis (4). Cell permeable.
Product Categories/Family for SB-202190, inhibitor
References
1. PR Young et al. J. Biol. Chem. 1997 272:12116
2. SP Davies et al. Biochem. J. 2000 351:95
3. CL Manthey et al. J. Leukoc. Biol. 1998 64:409
4. S Nemoto et al. J. Biol. Chem. 1998 273:16415
2. SP Davies et al. Biochem. J. 2000 351:95
3. CL Manthey et al. J. Leukoc. Biol. 1998 64:409
4. S Nemoto et al. J. Biol. Chem. 1998 273:16415
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Product Notes
The SB-202190 (Catalog #AAA515060) is an Inhibitor and is intended for research purposes only. The product is available for immediate purchase. It is sometimes possible for the material contained within the vial of "SB-202190, Inhibitor" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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