Molecular Structure
AAL-993, inhibitor
AAL-993
Purity
>98% (TLC: 5% CH3OH/CH2Cl2; Rf=0.46); NMR conforms
Synonyms
AAL-993; BML-259 ; N-(5-Isopropylthiazol-2-yl)phenylacetamide; 2-((4-Pyridyl)methyl)amino-N-(3 (trifluoromethyl)phenyl)benzamide; inhibitor
Purity/Purification
>98% (TLC: 5% CH3OH/CH2Cl2; Rf=0.46); NMR conforms
Form/Format
Light yellow powder
CAS Number
269390-77-4
Molecular Formula
C20H16F3N3O
Melting Point
150-152 degree C
Activity
CDK5/p25 inhibitor
Reconstitution
May be dissolved in DMSO (>25 mg/ml) or DMF (30 mg/ml)
Solubilization
May be dissolved in DMSO (>25 mg/ml); or Ethanol (15 mg/ml)
Preparation and Storage
Store desiccated as supplied at ambient for up to 2 years. Store solutions at -20 degree C for up to 2 months.
Molecular Structure
Molecular Structure
Related Product Information for AAL-993, inhibitor
VEGF inhibitor
Potent inhibitor of Cdk5/p25 (IC50=64 nM). Inhibits Cdk2/cyclin E at slightly higher concentration (IC50=98nM)1. Protects cells against NAC-amyloid-induced cell death2. Cell permeable.
Scientific Background: A potent and selective inhibitor of VEGFR-1 (IC50=130nM), VEGFR-2 (IC50=23nM) and VEGFR-3 (IC50=18nM). At higher concentrations it inhibits PDGFR (640nM), c-Kit (236nM) and CSF-1R (380nM). Inactive at other kinases such as EGFR, FGFR-1, CDK-1, Tie-2, c-Met, IGF-1R, c-Src and c-Abl (1). X-ray crystal studies on AAL-993 complexed to the catalytic domain of diphosphorylated VEGFR- 2 indicates that it binds to an inactive conformation of the protein (2). Cell permeable and active in vivo. Inhibits VEGF-induced angiogenesis (mouse model) (1).
Potent inhibitor of Cdk5/p25 (IC50=64 nM). Inhibits Cdk2/cyclin E at slightly higher concentration (IC50=98nM)1. Protects cells against NAC-amyloid-induced cell death2. Cell permeable.
Scientific Background: A potent and selective inhibitor of VEGFR-1 (IC50=130nM), VEGFR-2 (IC50=23nM) and VEGFR-3 (IC50=18nM). At higher concentrations it inhibits PDGFR (640nM), c-Kit (236nM) and CSF-1R (380nM). Inactive at other kinases such as EGFR, FGFR-1, CDK-1, Tie-2, c-Met, IGF-1R, c-Src and c-Abl (1). X-ray crystal studies on AAL-993 complexed to the catalytic domain of diphosphorylated VEGFR- 2 indicates that it binds to an inactive conformation of the protein (2). Cell permeable and active in vivo. Inhibits VEGF-induced angiogenesis (mouse model) (1).
Product Categories/Family for AAL-993, inhibitor
References
1. CJ Helal et al. Bioorg. Med. Chem. Lett. 2004 14:5521
2. A Kazmierczak et al. Neurochem. Int. 2011 58:206
2. A Kazmierczak et al. Neurochem. Int. 2011 58:206
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Product Notes
The AAL-993 (Catalog #AAA515037) is an Inhibitor and is intended for research purposes only. The product is available for immediate purchase. It is sometimes possible for the material contained within the vial of "AAL-993, Inhibitor" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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