Molecular Structure
AR-A014418, inhibitor
AR-A014418
Purity
>98% (TLC: 10% CH3OH in CH2Cl2; Rf=0.51); NMR (conforms)
Synonyms
AR-A014418; Rapamycin; Sirolimus; Fermentation product; N-[(4-Methoxyphenyl) methyl]-N'-(5-nitro-2-thiazolyl) urea; inhibitor
Purity/Purification
>98% (TLC: 10% CH3OH in CH2Cl2; Rf=0.51); NMR (conforms)
Form/Format
Off white powder
CAS Number
487021-52-3
Molecular Formula
C12H12N4O4S
Activity
mTOR inhibitor
Reconstitution
Soluble in DMSO (50 mg/ml); or Ethanol (50 mg/ml).
Solubilization
May be dissolved in DMSO (30 mg/ml)
Preparation and Storage
Store desiccated as supplied at 4 degree C for up to 2 years. Store solutions at -20 degree C for up to 2 months.
Molecular Structure
Molecular Structure
Related Product Information for AR-A014418, inhibitor
GSK3beta inhibitor
Potent immunosuppressant. The rapamycin-FKBP12 complex binds to and inhibits mTOR1. Inhibits IL-2-induced activation of p70 S6 kinase2. Extends lifespan of mice3. Induces autophagy in a variety of cell lines4.
Scientific Background: Selective glycogen synthase kinase 3 (GSK-3) inhibitor (IC50=104 nM). Inhibits beta-amyloid-mediated neurodegeneration in hippocampal slices. Antiinflammatory activity. Cell permeable. Active in rodent models.
Potent immunosuppressant. The rapamycin-FKBP12 complex binds to and inhibits mTOR1. Inhibits IL-2-induced activation of p70 S6 kinase2. Extends lifespan of mice3. Induces autophagy in a variety of cell lines4.
Scientific Background: Selective glycogen synthase kinase 3 (GSK-3) inhibitor (IC50=104 nM). Inhibits beta-amyloid-mediated neurodegeneration in hippocampal slices. Antiinflammatory activity. Cell permeable. Active in rodent models.
Product Categories/Family for AR-A014418, inhibitor
References
S Huang et al. Cancer Biol. Ther. 2003 2:222
2. CJ Kuo et al. Nature 1992 358:70
3. DE Harrison et al. Nature 2009 460:392
4. A Flemming et al. Nat. Chem. Biol. 2011 7:9
2. CJ Kuo et al. Nature 1992 358:70
3. DE Harrison et al. Nature 2009 460:392
4. A Flemming et al. Nat. Chem. Biol. 2011 7:9
Similar Products
Product Notes
The AR-A014418 (Catalog #AAA515047) is an Inhibitor and is intended for research purposes only. The product is available for immediate purchase. It is sometimes possible for the material contained within the vial of "AR-A014418, Inhibitor" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
If you are ready to order, navigate to Shopping Cart and get ready to checkout.
