IL2 Protein Recombinant Protein | IL2 recombinant protein

Recombinant Mouse IL2 Protein (His Tag)

Cat. Num. AAA2569313

• Gene Names: Il2; Il-2
• Purity: >90% as determined by reducing SDS-PAGE
• Synonyms: IL2 Protein; Recombinant Mouse IL2 Protein (His Tag); Aldesleukin; IL 2; IL-2; IL2; Interleukin 2; Interleukin-2; Involved in regulation of T cell clonal expansion; Lymphokine; OTTHUMP00000164090; POIL2; T Cell Growth Factor; T-cell growth factor; TCGF; IL2 recombinant protein

• Host: E Coli
• Purity/Purification: >90% as determined by reducing SDS-PAGE
• Form/Format: Lyophilized from sterile PBS, pH7.4
• Sequence: Ala21-Gln169

• Species: Mouse
• Tag: N-His
• Protein Construction: A DNA sequence encoding the Mouse IL2 (P04351-1)(Ala21-Gln169) was expressed with a polyhistidine tag at the N-terminus.
• Preparation and Storage: Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80 degree C. Reconstituted protein solution can be stored at 4-8 degree C for 2-7 days. Aliquots of reconstituted samples are stable at < -20 degree C for 3 months.; This product is provided as lyophilized powder which is shipped with ice packs.

SDS-Page

Related Product Information for IL2 recombinant protein

IL2 is a secreted cytokine involved in the operation and regulation of immune system. IL2 plays a pivotal role in T-cell activation and effector functions,including T cell proliferation,interferon-gammaproduction and cytotoxicity. IL2 can stimulate the propagation of lymphocytes and induce the cytotoxic T lymphocytes and lymphokine-activated killer cells for tumor cells. IL2 also influences memory T cell homeostasis through the regulation of memory T cell numbers and enhances major histocompatibility complex II (MHC II) expression on tumor cells.

NCBI and Uniprot Product Information

• NCBI GI #: 7110653
• NCBI GeneID: 16183
• NCBI Accession #: NP_032392.1
• NCBI GenBank Nucleotide #: NM_008366.3
• UniProt Accession #: P04351; P97945; Q791T3
• Molecular Weight: 43,000
• NCBI Official Full Name: interleukin-2
• NCBI Official Synonym Full Names: interleukin 2
• NCBI Official Symbol: Il2
• NCBI Official Synonym Symbols: Il-2
• NCBI Protein Information: interleukin-2; TCGF; T-cell growth factor
• UniProt Protein Name: Interleukin-2
• Protein Family: Interleukin
• UniProt Gene Name: Il2
• UniProt Synonym Gene Names: Il-2; IL-2; TCGF
• UniProt Entry Name: IL2_MOUSE

Uniprot Description

IL2: Produced by T-cells in response to antigenic or mitogenic stimulation, this protein is required for T-cell proliferation and other activities crucial to regulation of the immune response. Can stimulate B-cells, monocytes, lymphokine- activated killer cells, natural killer cells, and glioma cells. A chromosomal aberration involving IL2 is found in a form of T-cell acute lymphoblastic leukemia (T-ALL). Translocation t(4;16)(q26;p13) with involves TNFRSF17. Belongs to the IL-2 family.

Protein type: Secreted, signal peptide; Secreted; Oncoprotein; Cytokine

Cellular Component: extracellular space; cell; extracellular region; cytosol

Molecular Function: growth factor activity; interleukin-2 receptor binding; cytokine activity; carbohydrate binding; glycosphingolipid binding; kappa-type opioid receptor binding

Biological Process: positive regulation of interleukin-17 production; positive regulation of isotype switching to IgG isotypes; regulation of T cell homeostatic proliferation; positive regulation of regulatory T cell differentiation; negative regulation of heart contraction; immune system process; positive regulation of immunoglobulin secretion; positive regulation of activated T cell proliferation; negative regulation of lymphocyte proliferation; G-protein coupled receptor protein signaling pathway; elevation of cytosolic calcium ion concentration; positive regulation of interferon-gamma production; negative regulation of protein amino acid phosphorylation; positive regulation of T cell differentiation; positive regulation of tyrosine phosphorylation of Stat5 protein; negative regulation of inflammatory response; protein kinase C activation; positive regulation of B cell proliferation; positive regulation of T cell proliferation; positive regulation of transcription from RNA polymerase II promoter; immune response; positive regulation of protein amino acid phosphorylation; negative regulation of B cell apoptosis