Human Retinol Binding Protein/ RBP4 ELISA Kit | RBP elisa kit
Retinol Binding Protein (RBP) / RBP4 ELISA
Principle of the Assay: The murine TNF-alpha Kit is a solid phase sandwich Enzyme Linked-Immuno-Sorbent Assay (ELISA). A monoclonal antibody specific for mTNFalpha has been coated onto the wells of the microtiter strips provided. The antigen and a biotinylated polyclonal antibody specific for mTNFalpha are simultaneously incubated. Revelation step includes Streptavidin-Horse Radish peroxidase and TMB as chromogen.
NCBI and Uniprot Product Information
NCBI Description
This protein belongs to the lipocalin family and is the specific carrier for retinol (vitamin A alcohol) in the blood. It delivers retinol from the liver stores to the peripheral tissues. In plasma, the RBP-retinol complex interacts with transthyretin which prevents its loss by filtration through the kidney glomeruli. A deficiency of vitamin A blocks secretion of the binding protein posttranslationally and results in defective delivery and supply to the epidermal cells. [provided by RefSeq, Jul 2008]
Uniprot Description
RBP4: Delivers retinol from the liver stores to the peripheral tissues. In plasma, the RBP-retinol complex interacts with transthyretin, this prevents its loss by filtration through the kidney glomeruli. Defects in RBP4 are a cause of retinol-binding protein deficiency (RBP deficiency). This condition causes night vision problems. It produces a typical 'fundus xerophthalmicus', featuring a progressed atrophy of the retinal pigment epithelium. Belongs to the calycin superfamily. Lipocalin family.
Protein type: Secreted; Secreted, signal peptide
Chromosomal Location of Human Ortholog: 10q23.33
Cellular Component: extracellular space; protein complex; extracellular region; cytosol
Molecular Function: protein binding; protein heterodimerization activity; retinol binding; retinal binding
Biological Process: cardiac muscle development; phototransduction, visible light; retinal metabolic process; response to retinoic acid; urinary bladder development; maintenance of gastrointestinal epithelium; embryonic skeletal development; heart development; male gonad development; vagina development; positive regulation of insulin secretion; positive regulation of immunoglobulin secretion; glucose homeostasis; uterus development; response to insulin stimulus; gluconeogenesis; embryonic organ morphogenesis; response to ethanol; eye development; retinol metabolic process; negative regulation of cardiac muscle cell proliferation; embryonic retina morphogenesis in camera-type eye; detection of light stimulus involved in visual perception; spermatogenesis; retinoid metabolic process; female genitalia morphogenesis; lung development
Disease: Retinal Dystrophy, Iris Coloboma, And Comedogenic Acne Syndrome; Microphthalmia, Isolated, With Coloboma 10
Research Articles on RBP
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Product Notes
The Human RBP rbp4 (Catalog #AAA495091) is an ELISA Kit and is intended for research purposes only. The product is available for immediate purchase. The AAA495091 ELISA Kit recognizes Human RBP. It is sometimes possible for the material contained within the vial of "Retinol Binding Protein/ RBP4, ELISA Kit" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
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