Typical Testing Data/Standard Curve (for reference only)
HMG-CoA Reductase Activity/Inhibitor Screening Kit Assay Kit
HMG-CoA Reductase Activity / Inhibitor Screening Kit (Colorimetric)
Synonyms
HMG-CoA Reductase Activity/Inhibitor Screening Kit; HMG-CoA Reductase Activity / Inhibitor Screening Kit (Colorimetric); HMGR Activity/Inhibitor Screening Kit (Colorimetric); 3-hydroxy-3-methyl-glutaryl-CoA reductase Activity/Inhibitor Screening Kit (Colorimetric); HMG-CoA Reductase Activity/Inhibitor Screening Kit assay kit
Application Notes
Measurement of HMG-CoA reductase activity
Screening/studying/characterizing HMG-CoA reductase inhibitors/activators
Screening/studying/characterizing HMG-CoA reductase inhibitors/activators
Preparation and Storage
At -20 degree C
Shelf Life: 12 months
Shelf Life: 12 months
Typical Testing Data/Standard Curve (for reference only)
Typical Testing Data/Standard Curve (for reference only)
Related Product Information for HMG-CoA Reductase Activity/Inhibitor Screening Kit assay kit
Background/Introduction: HMG-CoA reductase (3-hydroxy-3-methyl-glutaryl-CoA reductase or HMGR) (EC 1.1.1.34) is the rate-controlling enzyme of the mevalonate pathway, the metabolic pathway that produces cholesterol from acetyl-CoA. In an NADPH-dependent reaction, HMG-CoA reductase reduces HMG-CoA to generate mevalonate and CoA. The enzyme is target of a group of cholesterol-lowering drugs known as statins. Inhibition of HMG-CoA reductase induces expression of LDL receptors in the liver, which lowers plasma concentration of cholesterol. The HMG-CoA Reductase Activity Assay Kit measures utilization of NADPH, which can be measured by the decrease of absorbance (OD 340 nm). The kit is suitable for measuring activity of purified enzyme and screening inhibitors/activators of HMG-CoA reductase. The limit of detection is below 0.05 mU.
Product Categories/Family for HMG-CoA Reductase Activity/Inhibitor Screening Kit assay kit
Similar Products
Product Notes
The HMG-CoA Reductase Activity/Inhibitor Screening Kit (Catalog #AAA841908) is an Assay Kit and is intended for research purposes only. The product is available for immediate purchase. Measurement of HMG-CoA reductase activity Screening/studying/characterizing HMG-CoA reductase inhibitors/activators. Researchers should empirically determine the suitability of the HMG-CoA Reductase Activity/Inhibitor Screening Kit for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "HMG-CoA Reductase Activity/Inhibitor Screening Kit, Assay Kit" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
If you are ready to order, navigate to Shopping Cart and get ready to checkout.
