HE4 Recombinant Protein | WFDC2 recombinant protein

HE4 Protein, Mouse, Recombinant (His Tag)

Cat. Num. AAA8122942

• Gene Names: Wfdc2; HE4; WAP5; 1600023A02Rik
• Purity: >85% as determined by SDS-PAGE
• Synonyms: HE4; HE4 Protein; Mouse; Recombinant (His Tag); Mouse WAP5/WFDC2/HE4 Protein (His Tag); 1600023A02Rik Protein; WAP5 Protein; WAP four-disulfide core domain 2; WFDC2 recombinant protein

• Host: HEK293 Cells
• Purity/Purification: >85% as determined by SDS-PAGE
• Form/Format: Lyophilized from sterile PBS, pH7.4. Normally 5%-8% trehalose, mannitol and 0.01% Tween80 are added as protectants before lyophilization. Please refer to the specific buffer information in the hard copy of CoA.
• Sequence: Met1-Phe174

• Species: Mouse
• Endotoxin: <1.0EU per ug protein as determined by the LAL method.
• Predicted N Terminal: Thr 26
• Tag: C-His
• Protein Construction: A DNA sequence encoding the mouse Wfdc2 (NP_080599.1)(Met1-Phe174) was expressed with a polyhistidine tag at the C-terminus.
• Reconstitution: A hardcopy of COA with reconstitution instruction is sent along with the products. Please refer to it for detailed information.
• Preparation and Storage: Samples are stable for up to twelve months from date of receipt at -20 degree C to -80 degree C. Store it under sterile conditions at -20 degree C to -80 degree C. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.; In general, recombinant proteins are provided as lyophilized powder which are shipped at ambient temperature. Bulk packages of recombinant proteins are provided as frozen liquid.; They are shipped out with blue ice.

SDS-Page

Related Product Information for WFDC2 recombinant protein

Background: WAP four-disulfide core domain protein 2, also known as Epididymal secretory protein E4, Major epididymis-specific protein E4, Putative protease inhibitor WAP5, WFDC2 and HE4, is a secreted protein that contains two WAP domains. WFDC2/HE4 is a member of a family of stable 4-disulfide core proteins that are secreted at high levels. It is expressed in a number of normal tissues, including male reproductive system, regions of the respiratory tract and nasopharynx. It is highly expressed in a number of tumors cells lines, such ovarian, colon, breast, lung and renal cells lines. Initially described as being exclusively transcribed in the epididymis. WFDC2 may be a component of the innate immune defences of the lung, nasal and oral cavities and suggest that WFDC2 functions in concert with related WAP domain containing proteins in epithelial host defence. WFDC2 re-expression in lung carcinomas may prove to be associated with tumour type and should be studied in further detail. Mammary gland expression of tammar WFDC2 during the course of lactation showed WFDC2 was elevated during pregnancy, reduced in early lactation and absent in mid-late lactation. WFDC2/HE4 can undergo a complex series of alternative splicing events that can potentially yield five distinct WAP domain containing protein isoforms.

Product Categories/Family for WFDC2 recombinant protein

Serine Proteases and Regulators

References

Bingle,L. et al., 2002, Oncogene. 21 (17):2768-73. Hellstrom,I. et al., 2003, Cancer Res. 63 (13):3695-700. Bingle,L. et al., 2006, Respir Res. 7 : 61. Galgano,M.T. et al., 2006, Mod Pathol.19 (6):847-53. Sharp,J.A. et al., 2007, Evol Dev. 9 (4): 378-92.

NCBI and Uniprot Product Information

• NCBI GI #: 21312840
• NCBI GeneID: 67701
• NCBI Accession #: NP_080599.1
• NCBI GenBank Nucleotide #: NM_026323.2
• Molecular Weight: 18,032 Da
• NCBI Official Full Name: WAP four-disulfide core domain protein 2
• NCBI Official Synonym Full Names: WAP four-disulfide core domain 2
• NCBI Official Symbol: Wfdc2
• NCBI Official Synonym Symbols: HE4; WAP5; 1600023A02Rik
• NCBI Protein Information: WAP four-disulfide core domain protein 2
• Protein Family: WAP four-disulfide core domain protein