Molecular Structure
STO-609, inhibitor
STO-609
Purity
>98% (TLC); NMR (Conforms)
Synonyms
STO-609; SU-4312; 3-(4-Dimethylaminobenzylidene)-1; 3-dihydroindol-2-one; DMBI; 7-oxo-7H-benzimidazo[2; 1-a]benz[de]isoquinoline-3-carboxylic acid acetate; inhibitor
Purity/Purification
>98% (TLC); NMR (Conforms)
Form/Format
Yellow powder
CAS Number
52029-86-4
Molecular Formula
C19H10N2O3 - CH3COOH
Activity
VEGFR; PDGFR inhibitor
Reconstitution
May be dissolved in DMSO (25 mg/ml)
Solubilization
May be dissolved in: DMSO (10 mg/ml)
Preparation and Storage
Store desiccated as supplied at ambient temperature for up to 2 years. Store solutions at -20 degree C for up to 3 months.
Molecular Structure
Molecular Structure
Related Product Information for STO-609, inhibitor
CAMKK inhibitor
Potent and selective inhibitor of VEGF receptor tyrosine kinase (Flk-1, KDR). Inhibits unactivated kinase 100-fold greater (IC50=0.04 uM) than activated kinase (IC50=4.0 uM)1. Weak inhibitor of PDGF receptor tyrosine kinase (IC50=19.4 uM)2. Inhibits endothelial cell activation and angiogenesis in a mouse model of Alzheimers disease3.
Scientific Background: Selective inhibitor of Ca2+-calmodulin-dependent protein kinase kinase (Ki = 80 and 15 ng/ml for inhibition of CaM-KKalpha and CaM-KKbeta respectively). Binds to the ATP-binding site. Displays >80-fold selectivity over CaMK1, CaMK2, CaMK4, MLCK, PKC, PKA and p42 MAPK. Cell permeable.
Potent and selective inhibitor of VEGF receptor tyrosine kinase (Flk-1, KDR). Inhibits unactivated kinase 100-fold greater (IC50=0.04 uM) than activated kinase (IC50=4.0 uM)1. Weak inhibitor of PDGF receptor tyrosine kinase (IC50=19.4 uM)2. Inhibits endothelial cell activation and angiogenesis in a mouse model of Alzheimers disease3.
Scientific Background: Selective inhibitor of Ca2+-calmodulin-dependent protein kinase kinase (Ki = 80 and 15 ng/ml for inhibition of CaM-KKalpha and CaM-KKbeta respectively). Binds to the ATP-binding site. Displays >80-fold selectivity over CaMK1, CaMK2, CaMK4, MLCK, PKC, PKA and p42 MAPK. Cell permeable.
Product Categories/Family for STO-609, inhibitor
References
1. RL Kendall et al. J. Biol. Chem. 1999 274:6453 2. L Sun et al. J. Med. Chem. 1998 41:2588 3. Schultheiss et al. Angiogenesis 2006 9:59
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Product Notes
The STO-609 (Catalog #AAA515066) is an Inhibitor and is intended for research purposes only. The product is available for immediate purchase. It is sometimes possible for the material contained within the vial of "STO-609, Inhibitor" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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