Molecular Structure
Necrostatin-1, Inhibitor
Necrostatin-1
Purity
>98% (TLC: 1:9, CH3OH:CH2Cl2; Rf=0.6); NMR (Conforms)
Synonyms
Necrostatin-1; AG-1296; 6; 7-Dimethoxy-3-phenylquinoxaline; inhibitor
Purity/Purification
>98% (TLC: 1:9, CH3OH:CH2Cl2; Rf=0.6); NMR (Conforms)
Form/Format
Yellow powder
CAS Number
4311-88-0
Molecular Formula
C13H13N3OS
Activity
PDGFR inhibitor
Reconstitution
May be dissolved in DMSO
Solubilization
May be dissolved DMSO (25 mg/ml); or ethanol (6 mg/ml)
Preparation and Storage
Store desiccated as supplied at ambient for up to 2 years. Store solutions at -20 degree C for up to 3 months.
Molecular Structure
Molecular Structure
Related Product Information for Necrostatin-1, inhibitor
RIP1 kinase inhibitor
A potent inhibitor of PDGF receptor tyrosine kinase (PDGFRalpha and beta), IC50=1 uM (1). Also inhibits FGF receptor tyrosine kinase (2), c-kit (3) and FLT3 (4) and reverses transformation induced by activated FLT3 (5). Induces apoptosis in a small-cell lung cancer cell line (H526) (3). Cell permeable.
Scientific Background: Inhibits cellular necroptosis a non-apoptotic cell death pathway which leads to necrosis (EC50 = 494 nM) (1). Inhibits receptor-interacting protein kinase 1 (RIPK1) (EC50 = 182 nM) the key upstream kinase in the necroptosis activation pathway (2,3). Reduces ischemic brain injury in a mouse model of stroke1 and inhibits myocardial death (4).
A potent inhibitor of PDGF receptor tyrosine kinase (PDGFRalpha and beta), IC50=1 uM (1). Also inhibits FGF receptor tyrosine kinase (2), c-kit (3) and FLT3 (4) and reverses transformation induced by activated FLT3 (5). Induces apoptosis in a small-cell lung cancer cell line (H526) (3). Cell permeable.
Scientific Background: Inhibits cellular necroptosis a non-apoptotic cell death pathway which leads to necrosis (EC50 = 494 nM) (1). Inhibits receptor-interacting protein kinase 1 (RIPK1) (EC50 = 182 nM) the key upstream kinase in the necroptosis activation pathway (2,3). Reduces ischemic brain injury in a mouse model of stroke1 and inhibits myocardial death (4).
Product Categories/Family for Necrostatin-1, inhibitor
References
1. M Kovalenko et al. Biochemistry 1997 36:6260 2. F Strutz et al. Kidney Int. 2001 59:579 3. G W Krystal et al. Cancer Res. 1997 57:2203 4. R Grundler et al. Blood 2003 102:646 5. KF Tse et al. Leukemia 2001 15:1001
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Product Notes
The Necrostatin-1 (Catalog #AAA515041) is an Inhibitor and is intended for research purposes only. The product is available for immediate purchase. It is sometimes possible for the material contained within the vial of "Necrostatin-1, Inhibitor" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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