Molecular Structure
Src I1, inhibitor
Src I1
Purity
98% (TLC; 5% CH3OH in CH2Cl2; Rf=0.43); NMR (Conforms)
Synonyms
Src I1; LFM-A13; 2-Cyano-N-(2; 5-dibromophenyl)-3-hyd-roxy-2-butenamide; 6; 7-Dimethoxy-N-(4-phenoxyphenyl)-4-quinazolinamine; inhibitor
Purity/Purification
98% (TLC; 5% CH3OH in CH2Cl2; Rf=0.43); NMR (Conforms)
Form/Format
White solid
CAS Number
179248-59-0
Molecular Formula
C22H19N3O3
Melting Point
243-245 degree C
Activity
BTK Inhibitor
Reconstitution
DMSO (10 mg/ml) and ethanol (15 mg/ml)
Solubilization
Soluble in DMSO (15 mg/ml); Ethanol (nil)
Preparation and Storage
Store desiccated as supplied at ambient temperature for up to 3 years. Store solutions at -20 degree C for up to 3 months.
Molecular Structure
Molecular Structure
Related Product Information for Src I1, inhibitor
Src kinase inhibitor
Potent and selective inhibitor of Bruton's tyrosine kinase (BTK). Inhibits recombinant BTK with an IC50 = 2.5 uM1 and has no activity at other protein kinases (including JAK1, JAK3, HCK, EGFR kinase and insulin receptor kinase) at concentrations up to 300 uM2.
Scientific Background: Potent, competitive dual site (ATP- and substrate-binding domains) Src and Lck inhibitor (IC50 = 44 and 88 nM respectively). Also inhibits VEGFR2 and c-fms at higher concentrations (IC50 = 0.32 and 30 uM respectively).
Potent and selective inhibitor of Bruton's tyrosine kinase (BTK). Inhibits recombinant BTK with an IC50 = 2.5 uM1 and has no activity at other protein kinases (including JAK1, JAK3, HCK, EGFR kinase and insulin receptor kinase) at concentrations up to 300 uM2.
Scientific Background: Potent, competitive dual site (ATP- and substrate-binding domains) Src and Lck inhibitor (IC50 = 44 and 88 nM respectively). Also inhibits VEGFR2 and c-fms at higher concentrations (IC50 = 0.32 and 30 uM respectively).
Product Categories/Family for Src I1, inhibitor
References
1. S Mahajan et al. J. Biol. Chem. 1999 274:9587 2. A Vassilev et al. J. Biol. Chem. 1999 274:1646
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Product Notes
The Src I1 (Catalog #AAA515021) is an Inhibitor and is intended for research purposes only. The product is available for immediate purchase. It is sometimes possible for the material contained within the vial of "Src I1, Inhibitor" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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