Molecular Structure
AG-879, inhibitor
AG-879
Purity
>98% (TLC); NMR (Conforms)
Synonyms
AG-879; AS-041164 ; 5-Benzo[1; 3]dioxol-5-ylmethylene-thiazolidine-2; 4-dione; NSC31098; alpha-Cyano-(3; 5-di-t-butyl-4-hydroxy)thiocinnamide; inhibitor
Purity/Purification
>98% (TLC); NMR (Conforms)
Form/Format
Yellow powder
CAS Number
148741-30-4
Molecular Formula
C18H24N2OS
Melting Point
223-224 degree C
Activity
PI3-K g inhibitor
Reconstitution
May be dissolved in DMSO (25 mg/mL)
Solubilization
May be dissolved in DMSO (25mg/ml) or Ethanol (20 mg/ml)
Preparation and Storage
Store desiccated as supplied at -20 degree C for up to 2 years. Store solutions at -20 degree C for up to 2 months.
Molecular Structure
Molecular Structure
Related Product Information for AG-879, inhibitor
NGFR inhibitor
A selective PI 3-Kg isoform inhibitor (IC50 = 0.24, 1.45, 0.07 and 1.70 uM for a, b, g and d isoforms respectively). Blocks neutrophil recruitment and displays anti-inflammatory activity1. Active in vivo.
Scientific Background: Inhibits NGF receptor tyrosine kinase (TrkA, pp140trk). Inhibits NGF-induced neurite outgrowth in PC12 cells (1). Displays antitumor activity in a mouse model (2). Blocks the ETK-PAK1 interaction, suppressing RAS-induced PAK1 activation and malignant transformation (3). Cell permeable.
A selective PI 3-Kg isoform inhibitor (IC50 = 0.24, 1.45, 0.07 and 1.70 uM for a, b, g and d isoforms respectively). Blocks neutrophil recruitment and displays anti-inflammatory activity1. Active in vivo.
Scientific Background: Inhibits NGF receptor tyrosine kinase (TrkA, pp140trk). Inhibits NGF-induced neurite outgrowth in PC12 cells (1). Displays antitumor activity in a mouse model (2). Blocks the ETK-PAK1 interaction, suppressing RAS-induced PAK1 activation and malignant transformation (3). Cell permeable.
Product Categories/Family for AG-879, inhibitor
References
1. C Ferrandi et al. J. Pharmacol. Exp. Ther. 2007 322:923
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Product Notes
The AG-879 (Catalog #AAA515054) is an Inhibitor and is intended for research purposes only. The product is available for immediate purchase. It is sometimes possible for the material contained within the vial of "AG-879, Inhibitor" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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