Chemical Structure
(Chemical structure of AG490 (SIH-428), a JAK-2 kinase inhibitor. CAS #: 133550-30-8. Molecular Formula: C17H14N2O3. Molecular Weight: 294.3 g/mol.)
AG490 small molecule
AG490
Purity
>=98% (TLC)
Synonyms
AG490; JAK-2 kinase inhibitor; Tyrphostin AG 490; N-Benzyl-3; 4-dihydroxybenzylidenecyanoacetamide; 2-Cyano-3-(3; 4-dihydroxyphenyl)-N-(benzyl)-2-propenamide; 4-dihydroxyphenyl)-N-(phenylmethyl)-2-propenamide; AG490 small molecule
Host
Synthetic
Purity/Purification
>=98% (TLC)
Form/Format
Tan solid
Solubility
Soluble in DMSO (30 mg/ml), dimethyl formamide (40 mg/ml) or 100% ethanol (10 mg/ml)
CAS Number
133550-30-8
Molecular Formula
C17H14N2O3
SMILES
C1=CC=C(C=C1)CNC(=O)C(=CC2=CC(=C(C=C2)O)O)C#N
InChI
1S/C17H14N2O3/c18-10-14(8-13-6-7-15(20)16(21)9-13)17(22)19-11-12-4-2-1-3-5-12/h1-9,20-21H,11H2,(H,19,22)/b14-8+
InChI Key
TUCIOBMMDDOEMM-RIYZIHGNSA-N
PubChem CID
5328779
Preparation and Storage
Store at -20 degree C.
Chemical Structure
(Chemical structure of AG490 (SIH-428), a JAK-2 kinase inhibitor. CAS #: 133550-30-8. Molecular Formula: C17H14N2O3. Molecular Weight: 294.3 g/mol.)
Chemical Structure
(Chemical structure of AG490 (SIH-428), a JAK-2 kinase inhibitor. CAS #: 133550-30-8. Molecular Formula: C17H14N2O3. Molecular Weight: 294.3 g/mol.)
Related Product Information for AG490 small molecule
AG490 is a selective inhibitor of JAK2/3 and EGF receptor tyrosine kinase. It also inhibits the downstream activation of STAT5a/b. AG490 is cell permeable and is a valuable tool for studying the cellular role of JAK kinases in signal transduction.
Product Categories/Family for AG490 small molecule
References
1. Abe M., et al. (2009) Int. Immunopharma. 9(7-8): 870-877. 2. De Vos J., Jourdan M., Tarte K., Jasmin C., & Klein B. (2000) British J. Haem. 109(4): 823-828. 3. Kirken R.A., et al. (1999) J. Leukocyte Biol. 65(6): 891-899.
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Product Notes
The AG490 (Catalog #AAA808130) is a Small Molecule produced from Synthetic and is intended for research purposes only. The product is available for immediate purchase. It is sometimes possible for the material contained within the vial of "AG490, Small Molecule" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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