Structure
AG-490, Inhibitor
AG-490
Purity
>98% (HPLC)
Synonyms
AG-490; AG 490; Tyrphostin AG 490; AG490; inhibitor
Purity/Purification
>98% (HPLC)
Suitability
10mM in DMSO
Target
JAK
Receptor
EGFR; HER2/ErbB2; JAK2
Chemical Name
2-Propenamide, 2-cyano-3-(3, 4-dihydroxyphenyl)-N-(phenylmethyl)-, (2E)
SMILES
O=C(NCC1=CC=CC=C1)/C(C#N)=C/C2=CC=C(O)C(O)=C2
Molecular Formula
C17H14N2O3
CAS Number
133550-30-8
Preparation and Storage
Store at -20 degree C
Stability: >=2 years
Shipping: Ice Pack
Stability: >=2 years
Shipping: Ice Pack
Structure
Structure
Related Product Information for AG-490, inhibitor
AG-490 (Tyrphostin AG 490) is a multi-targeted tyrphostin family of tyrosine kinase inhibitor, inhibits EGF receptor tyrosine kinase with IC50 of 2 and 13.5uM for EGFR and ErbB2, also inhibits JAK2, JAK3/STAT, JAK3/AP-1 and JAK3/MAPK pathways; selectively blocks leukaemic cell growth in vitro and in vivo by inducing programmed cell death, blocks the constitutive activation of Stat3 and inhibits spontaneous as well as IL2-induced growth of MF tumor cells. Blood Cancer Discontinued
Product Categories/Family for AG-490, inhibitor
References
1. Dadi H, et al. Blood. 1994 Sep 1; 84 (5):1579-86.
2. Nielsen M, et al. Proc Natl Acad Sci U S A. 1997 Jun 24; 94 (13):6764-9.
3. Meydan N, et al. Nature. 1996 Feb 15; 379 (6566):645-8.
4. Wang LH, et al. J Immunol. 1999 Apr 1; 162 (7):3897-904.
2. Nielsen M, et al. Proc Natl Acad Sci U S A. 1997 Jun 24; 94 (13):6764-9.
3. Meydan N, et al. Nature. 1996 Feb 15; 379 (6566):645-8.
4. Wang LH, et al. J Immunol. 1999 Apr 1; 162 (7):3897-904.
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Product Notes
The AG-490 (Catalog #AAA3601343) is an Inhibitor and is intended for research purposes only. The product is available for immediate purchase. It is sometimes possible for the material contained within the vial of "AG-490, Inhibitor" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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