K252A small molecule

K252A

Cat. Num. AAA808155

• Purity: >=98% (HPLC)
• Synonyms: K252A; Kinase inhibitor; (9S; 10R; 12R)-2; 3; 9; 10; 11; 12-Hexahydro-10-hydroxy-9-methyl-1-oxo-9; 12-epoxy-1H-diindolo[1; 2; 3-fg:3'; 2'; 1'-kl]pyrrolo[3; 4-i][1; 6]benzodiazocine-10-carboxylic acid methyl ester; K252A small molecule

• Host: Nonomuraea longicatena
• Purity/Purification: >=98% (HPLC)
• Form/Format: White solid

• Solubility: Soluble to 25 mM in DMSO
• CAS Number: 99533-80-9
• Molecular Formula: C27H21N3O5
• SMILES: [N]47C1=C(C6=C(C2=C1[N](C3=CC=CC=C23)[C@@H]5O[C@]4(C(C5)(O)C(=O)OC)C)C(NC6)=O)C8=C7C=CC=C8
• InChI: 1S/C27H21N3O5/c1-26-27(33,25(32)34-2)11-18(35-26)29-16-9-5-3-7-13(16)20-21-15(12-28-24(21)31)19-14-8-4-6-10-17(14)30(26)23(19)22(20)29/h3-10,18,33H,11-12H2,1-2H3,(H,28,31)/t18?,26-,27-/m1/s1
• InChI Key: KOZFSFOOLUUIGY-CYBHFKQVSA-N
• PubChem CID: 11612445
• Preparation and Storage: Store at -20 degree C.

Chemical Structure

(Chemical structure of K252A (SIH-455), a Kinase inhibitor (pan-specific). CAS #: 99533-80-9. Molecular Formula: C27H21N3O5. Molecular Weight: 467.5 g/mol.)

Related Product Information for K252A small molecule

K252A is a non-selective protein kinase inhibitor that exhibits a wide range of effects. Specifically, it has been seen to inhibit PKA, PKC, PKG, CAM kinase II, mlCK, Ser/Thr kinase, Met, and receptor tyrosine kinases. It has been shown to prevent autophosphorylation and activation of downstream effectors.

Product Categories/Family for K252A small molecule

Small Molecules; Inhibitor; Cell Signaling; Cancer; Apoptosis; Cancer Growth Inhibitors; Tyrosine Kinase Inhibitors

References

1. Morotti A., Mila S., Accorner, P., Tagliabue E., & Ponzetto C. (2002) Oncogene. 21(32): 4885-4893. 2. Hashimoto Y., et al. (1991) Biochem. Biophys. Res. Comm. 181(1): 423-429. 3. Raychaudhuri S.P., Sanyal M., Weltman H., & Kundu-Raychaudhuri S. (2004) J. Invest. Derm. 122(3): 812-819.