Tudor domain-containing protein 4 (hTDRD4) Recombinant Protein | TDRD4 recombinant protein

Tudor domain-containing protein 4 (hTDRD4, domain 30-139aa), human recombinant

Cat. Num. AAA844247

• Gene Names: RNF17; TDRD4; Mmip-2; SPATA23
• Applications: SDS-Page
• Purity: >=98%
• Synonyms: Tudor domain-containing protein 4 (hTDRD4); Tudor domain-containing protein 4 (hTDRD4; domain 30-139aa); human recombinant; RING finger protein 17; Tudor domain-containing protein 4; TDRD4; RNF17; TDRD4 recombinant protein

• Host: E Coli
• Purity/Purification: >=98%
• Form/Format: 1.0 mg/ml solution in 25 mM Tris (pH 8.0) buffer containing 20% glycerol.; Appearance: Liquid
• Concentration: 1 mg/ml (varies by lot)
• Sequence Length: 1623

• Applicable Applications for TDRD4 recombinant protein: SDS-PAGE; HPLC
• Handling: Centrifuge the vial prior to opening.
• Preparation and Storage: At -80 degree C; Shelf Life: 12 months

Testing Data

Related Product Information for TDRD4 recombinant protein

Background: Tudor domains are small protein structural motifs of about ~50 amino acids related to the "royal family" of methyl readers, which also includes chromo, MBT, PWWP, and Agenet-like domains. Tudor domains occur either alone, in tandem, or with other domains and are found in many proteins that are involved in RNA metabolism, germ cell development, transposon silencing, DNA damage response, histone modification, and chromatin remodeling. The Tudor domains recognize symmetric methylated arginine or methylated lysine residues. Tudor domain proteins act as an oncogene and play a very important role in HCC and colon cancer. TDRD is also involved in RISC complex and interacts with AEG-1 oncogene. The Tudor domain can bind to methylated arginine protein and promote tumor angiogenesis in human hepatocellular carcinoma, etc. TDRD4 is a candidate CT antigen expressed in a subset of liver cancers. The recombinant protein includes TDRD4 (domain 30-139 aa) with N-terminal His-tag.

Product Categories/Family for TDRD4 recombinant protein

Epigenetics; Reader Domains; Tudor Domains; Tudor Domain ProteinsProteins and Enzymes; Animal-Free Origin (AOF) Recombinant Proteins & EnzymesProteins and Enzymes; Proteins and Enzymes (A-Z)

NCBI and Uniprot Product Information

• NCBI GI #: 94421471
• NCBI GeneID: 56163
• NCBI Accession #: NP_112567.2
• NCBI GenBank Nucleotide #: NM_031277.2
• UniProt Accession #: Q9BXT8; Q5T2J9; Q6P1W3; Q9BXT7; Q9NUY9
• Molecular Weight: 14.6 kDa (110 aa + NT 6 x His-tag)
• NCBI Official Full Name: RING finger protein 17 isoform 1
• NCBI Official Synonym Full Names: ring finger protein 17
• NCBI Official Symbol: RNF17
• NCBI Official Synonym Symbols: TDRD4; Mmip-2; SPATA23
• NCBI Protein Information: RING finger protein 17
• UniProt Protein Name: RING finger protein 17
• UniProt Gene Name: RNF17
• UniProt Synonym Gene Names: TDRD4
• UniProt Entry Name: RNF17_HUMAN

NCBI Description

This gene is similar to a mouse gene that encodes a testis-specific protein containing a RING finger domain. Alternatively spliced transcript variants encoding different isoforms have been found. [provided by RefSeq, May 2010]

Uniprot Description

RNF17: Seems to be involved in regulation of transcriptional activity of MYC. In vitro, inhibits DNA-binding activity of Mad- MAX heterodimers. Can recruit Mad transcriptional repressors (MXD1, MXD3, MXD4 and MXI1) to the cytoplasm. May be involved in spermiogenesis. 5 isoforms of the human protein are produced by alternative splicing.

Protein type: Cancer Testis Antigen (CTA)

Chromosomal Location of Human Ortholog: 13q12.12

Cellular Component: cytoplasm; nucleus

Molecular Function: protein homodimerization activity; zinc ion binding

Biological Process: multicellular organismal development; spermatid development