BRD1 bromodomain Recombinant Protein | BRD1 recombinant protein

BRD1 bromodomain (556-688 aa) (His-Tag), human recombinant

Cat. Num. AAA844547

• Gene Names: BRD1; BRL; BRPF1; BRPF2
• Applications: SDS-Page
• Purity: >=95%
• Synonyms: BRD1 bromodomain; BRD1 bromodomain (556-688 aa) (His-Tag); human recombinant; Bromodomain containing 1; DKFZp686F0325; BR140-like protein; BRL; BRPF1; BRPF2; Bromodomain & PHD finger-containing protein 2; BRD1 recombinant protein

• Host: E Coli
• Purity/Purification: >=95%
• Form/Format: 0.5 mg/ml in Phosphate buffer saline (pH 7.4) containing 10% glycerol and 1mM DTT.; Appearance: Liquid
• Concentration: 0.5 mg/ml (varies by lot)
• Sequence Positions: 556-688
• Sequence: MGSSHHHHHH SSGLVPRGSH MGSEQVAMEL RLTPLTVLLR SVLDQLQDKD PARIFAQPVS LKEVPDYLDH IKHPMDFATM RKRLEAQGYK NLHEFEEDFD LIIDNCMKYN ARDTVFYRAA VRLRDQGGVV LRQARREVDS IGLEEASGMH LPERPA
• Sequence Length: 1189

• Applicable Applications for BRD1 recombinant protein: SDS-PAGE
• Handling: Centrifuge the vial prior to opening.
• Preparation and Storage: At -80 degree C; Shelf Life: 12 months

Testing Data

Related Product Information for BRD1 recombinant protein

Background: The acetylation of histone lysine residues plays a crucial role in the epigenetic regulation of gene transcription. A bromodomain is a protein domain that recognizes acetylated lysine residues such as those on the N-terminal tails of histones. This recognition is often a prerequisite for protein-histone association and chromatin remodeling. These domains function in the linking of protein complexes to acetylated nucleosomes, thereby controlling chromatin structure and gene expression. Thus, bromodomains serve as "readers" of histone acetylation marks regulating the transcription of target promoters. BRD1 is a bromodomain containing protein that has been identified as a susceptibility gene in neurological disorders, such as schizophrenia and bipolar affective disorder. This protein can be used for the study of bromodomain binding assays, screening inhibitors, and selectivity profiling. Recombinant human BRD1 protein, fused to His-tag at N-terminus, was expressed in E.coli and purified by using conventional chromatography techniques.

Product Categories/Family for BRD1 recombinant protein

Epigenetics; Reader Domains; Bromodomains; BromodomainsProteins and Enzymes; Other Proteins & EnzymesProteins and Enzymes; Animal-Free Origin (AOF) Recombinant Proteins & EnzymesProteins and Enzymes; Proteins and Enzymes (A-Z)

NCBI and Uniprot Product Information

• NCBI GI #: 756141031
• NCBI GeneID: 23774
• NCBI Accession #: NP_001291737.1
• NCBI GenBank Nucleotide #: NM_001304808.1
• UniProt Accession #: O95696; A6ZJA4
• Molecular Weight: 17.8 kDa (156 aa, 556-688 aa + His Tag), confirmed by MALDI-TOF.
• NCBI Official Full Name: bromodomain-containing protein 1 isoform 1
• NCBI Official Synonym Full Names: bromodomain containing 1
• NCBI Official Symbol: BRD1
• NCBI Official Synonym Symbols: BRL; BRPF1; BRPF2
• NCBI Protein Information: bromodomain-containing protein 1
• UniProt Protein Name: Bromodomain-containing protein 1
• UniProt Gene Name: BRD1
• UniProt Synonym Gene Names: BRL; BRPF2
• UniProt Entry Name: BRD1_HUMAN

NCBI Description

This gene encodes a bromodomain-containing protein that localizes to the nucleus and can interact with DNA and histone tails. The encoded protein is a component of the MOZ/MORF acetyltransferase complex and can stimulate acetylation of histones H3 and H4, thereby potentially playing a role in gene activation. Variation in this gene is associated with schozophrenia and bipolar disorder in some study populations. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2015]

Uniprot Description

BRD1: a nuclear protein containing a bromo-domain, a PHD domain, and a PWWP domain. Encoded by a susceptibility gene for schizophrenia and bipolar affective disorder. May play a role in neurodevelopment.

Protein type: Cell development/differentiation

Chromosomal Location of Human Ortholog: 22q13.33

Cellular Component: nucleoplasm; nucleus

Molecular Function: zinc ion binding; histone binding