Western Blot (WB)
(Western blot analysis of TTYH2 in human kidney tissue lysate with TTYH2 antibody at 1 μg/ml)
Rabbit TTYH2 Polyclonal Antibody | anti-TTYH2 antibody
TTYH2 Antibody
Gene Names
TTYH2; C17orf29
Reactivity
Human, Mouse, Rat
Applications
ELISA, Western Blot, Immunohistochemistry, Immunofluorescence
Purity
TTYH2 Antibody is affinity chromatography purified via peptide column.
Synonyms
TTYH2; Polyclonal Antibody; TTYH2 Antibody; C17orf29; Protein tweety homolog 2; hTTY2; tweety homolog 2 (Drosophila); anti-TTYH2 antibody
Host
Rabbit
Reactivity
Human, Mouse, Rat
Clonality
Polyclonal
Isotype
IgG
Specificity
At least four isoforms of TTYH2 are known to exist; this antibody will only detect the two longest isoforms. This antibody is predicted to not cross-react with other TTYH family members.
Purity/Purification
TTYH2 Antibody is affinity chromatography purified via peptide column.
Form/Format
Liquid
Concentration
1 mg/mL (varies by lot)
Sequence Length
534
Applicable Applications for anti-TTYH2 antibody
ELISA (EIA), Western Blot (WB), Immunohistochemistry (IHC), Immunofluorescence (IF)
Application Notes
TTYH2 antibody can be used for detection of TTYH2 by Western blot at 1 mug/mL. Antibody can also be used for immunohistochemistry starting at 2.5 mug/mL. For immunofluorescence start at 2.5 mug/mL.
Conjugate
Unconjugated
Immunogen
TTYH2 antibody was raised against a 14 amino acid synthetic peptide near the amino terminus of human TTYH2.
Buffer
TTYH2 Antibody is supplied in PBS containing 0.02% sodium azide.
Preparation and Storage
TTYH2 antibody can be stored at 4 degree C for three months and -20 degree C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Western Blot (WB)
(Western blot analysis of TTYH2 in human kidney tissue lysate with TTYH2 antibody at 1 μg/ml)
Western Blot (WB)
(Western blot analysis of TTYH2 in human kidney tissue lysate with TTYH2 antibody at 1 μg/ml)
Immunohistochemistry (IHC)
(Immunohistochemistry of TTYH2 in human kidney tissue with TTYH2 antibody at 2.5 μg/mL.)
Immunohistochemistry (IHC)
(Immunohistochemistry of TTYH2 in human kidney tissue with TTYH2 antibody at 2.5 μg/mL.)
Immunofluorescence (IF)
(Immunofluorescence of TTYH2 in human kidney tissue with TTYH2 antibody at 20 μg/mL.)
Immunofluorescence (IF)
(Immunofluorescence of TTYH2 in human kidney tissue with TTYH2 antibody at 20 μg/mL.)
Related Product Information for anti-TTYH2 antibody
TTYH2 Antibody: TTYH2 is a member of the tweety family of proteins, a family of chloride anion channels containing five transmembrane regions. TTYH2 is a Ca2+-activated large conductance chloride (Cl-) channel and may play a role in kidney tumorigenesis. It is also upregulated in colon carcinoma and is thought to play a role in cell proliferation and call aggregation, suggesting that TTYH2 may play a role in regulating both proliferation and metastatic potentials of colorectal cancer. The ubiquitin-protein ligase Nedd4-2 binds to and ubiquitinates TTYH2, thereby regulating its cell surface expression and total cellular levels.
NCBI and Uniprot Product Information
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
Molecular Weight
23,562 Da
NCBI Official Full Name
protein tweety homolog 2 isoform 1
NCBI Official Synonym Full Names
tweety family member 2
NCBI Official Symbol
TTYH2
NCBI Official Synonym Symbols
C17orf29
NCBI Protein Information
protein tweety homolog 2; hTTY2
UniProt Protein Name
Protein tweety homolog 2
Protein Family
UniProt Gene Name
TTYH2
UniProt Synonym Gene Names
C17orf29; hTTY2
UniProt Entry Name
TTYH2_HUMAN
NCBI Description
This gene encodes a member of the tweety family of proteins. Members of this family function as chloride anion channels. The encoded protein functions as a calcium(2+)-activated large conductance chloride(-) channel, and may play a role in kidney tumorigenesis. Two transcript variants encoding distinct isoforms have been identified for this gene. [provided by RefSeq, Jul 2008]
Uniprot Description
TTYH2: Probable large-conductance Ca(2+)-activated chloride channel. May play a role in Ca(2+) signal transduction. May be involved in cell proliferation and cell aggregation. Belongs to the tweety family. 2 isoforms of the human protein are produced by alternative splicing.
Protein type: Transporter, ion channel; Channel, chloride; Membrane protein, integral; Membrane protein, multi-pass; Transporter
Chromosomal Location of Human Ortholog: 17q25.1
Cellular Component: plasma membrane
Molecular Function: chloride channel activity; protein binding
Research Articles on TTYH2
Similar Products
Product Notes
The TTYH2 ttyh2 (Catalog #AAA150067) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The TTYH2 Antibody reacts with Human, Mouse, Rat and may cross-react with other species as described in the data sheet. AAA Biotech's TTYH2 can be used in a range of immunoassay formats including, but not limited to, ELISA (EIA), Western Blot (WB), Immunohistochemistry (IHC), Immunofluorescence (IF). TTYH2 antibody can be used for detection of TTYH2 by Western blot at 1 mug/mL. Antibody can also be used for immunohistochemistry starting at 2.5 mug/mL. For immunofluorescence start at 2.5 mug/mL. Researchers should empirically determine the suitability of the TTYH2 ttyh2 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "TTYH2, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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