Rabbit anti-Human ZIP13 Polyclonal Antibody | anti-Slc39a13 antibody

ZIP13 Antibody

Cat. Num. AAA150218

• Reactivity: Human
• Applications: ELISA, Western Blot, Immunohistochemistry, Immunofluorescence
• Purity: ZIP13 Antibody is affinity chromatography purified via peptide column.
• Synonyms: ZIP13; Polyclonal Antibody; ZIP13 Antibody; Zinc transporter ZIP13; LIV-1 subfamily of ZIP zinc transporter 9; LZT-Hs9; solute carrier family 39 (zinc transporter); member 13; anti-Slc39a13 antibody

• Host: Rabbit
• Reactivity: Human
• Clonality: Polyclonal
• Isotype: IgG
• Specificity: At least two isoforms of ZIP13 are known to exist; this antibody will detect both isoforms. ZIP13 antibody is predicted to not cross-react with other ZIP family members.
• Purity/Purification: ZIP13 Antibody is affinity chromatography purified via peptide column.
• Form/Format: Liquid
• Concentration: 1 mg/mL (varies by lot)
• Sequence Length: 371

• Applicable Applications for anti-Slc39a13 antibody: ELISA (EIA), Western Blot (WB), Immunohistochemistry (IHC), Immunofluorescence (IF)
• Application Notes: ZIP13 antibody can be used for detection of ZIP13 by Western blot at 1 mug/mL. Antibody can also be used for immunohistochemistry starting at 2.5 mug/mL. For immunofluorescence start at 20 mug/mL.
• Conjugate: Unconjugated
• Immunogen: ZIP13 antibody was raised against a 14 amino acid synthetic peptide near the amino terminus of human ZIP13.
• Buffer: ZIP13 Antibody is supplied in PBS containing 0.02% sodium azide.
• Preparation and Storage: ZIP13 antibody can be stored at 4 degree C for three months and -20 degree C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Western Blot (WB)

(Western blot analysis of ZIP13 in K562 cell lysate with ZIP13 antibody at 1 μg/mL.)

Immunohistochemistry (IHC)

(Immunohistochemistry of ZIP13 in human spleen tissue with ZIP13 antibody at 2.5 μg/mL.)

Immunofluorescence (IF)

(Immunofluorescence of ZIP13 in human spleen tissue with ZIP13 antibody at 20 μg/mL.)

Related Product Information for anti-Slc39a13 antibody

ZIP13 Antibody: The zinc transporter ZIP13, also known as SLC39A13, is a member of a family of divalent ion transporters. Zinc is an essential ion for cells and plays significant roles in the growth, development, and differentiation. The zinc transporter family is divided into four subfamilies (I, II, LIV-1 and gufA). ZIP13 is a multipass membrane protein that belongs to the ZIP transporter subfamily LIV-1. Mutations in ZIP13 have recently been shown to cause a spondylocheiro dysplastic form of Ehlers-Danlos syndrome (SCD-EDS), a generalized skeletal dysplasia involving mainly the spine with clinical abnormalities of the hands in addition to EDS-like features. Other experiments have shown that ZIP13 is required for proper connective tissue development and is involved in BMP/TGF- signaling pathways.

NCBI and Uniprot Product Information

• NCBI GI #: 190014617
• NCBI GeneID: 91252
• NCBI Accession #: NP_001121697
• NCBI GenBank Nucleotide #: NM_001128225.2
• UniProt Accession #: Q96H72; Q659D9; Q8N7C9; Q8WV10; D3DQR6; D3DQR7; E9PLY1; E9PQV3
• Molecular Weight: 38,425 Da
• NCBI Official Full Name: zinc transporter ZIP13 isoform a
• NCBI Official Synonym Full Names: solute carrier family 39 (zinc transporter), member 13
• NCBI Official Symbol: SLC39A13
• NCBI Protein Information: zinc transporter ZIP13; LZT-Hs9; zrt- and Irt-like protein 13; LIV-1 subfamily of ZIP zinc transporter 9; solute carrier family 39 (metal ion transporter), member 13
• UniProt Protein Name: Zinc transporter ZIP13
• Protein Family: Zinc transporter
• UniProt Gene Name: SLC39A13
• UniProt Synonym Gene Names: ZIP13; LZT-Hs9; ZIP-13
• UniProt Entry Name: S39AD_HUMAN

NCBI Description

This gene encodes a member of the LIV-1 subfamily of the ZIP transporter family. The encoded transmembrane protein functions as a zinc transporter. Mutations in this gene have been associated with the spondylocheiro dysplastic form of Ehlers-Danlos syndrome.[provided by RefSeq, Mar 2010]

Uniprot Description

SLC39A13: Acts as a zinc-influx transporter. Defects in SLC39A13 are the cause of Ehlers-Danlos syndrome-like spondylocheirodysplasia (SCD-EDS). SCD- EDS is a 'spondylocheiro dysplastic form of Ehlers-Danlos syndrome'. The syndrome consists of a generalized skeletal dysplasia involving mainly the spine (spondylo) and striking clinical abnormalities of the hands (cheiro) in addition to the EDS-like features. Clinical features included postnatal growth retardation, moderate short stature, protuberant eyes with bluish sclerae, hands with finely wrinkled palms, atrophy of the thenar muscles, and tapering fingers. Patients have thin, hyperelastic skin and hypermobile small joints consistent with an Ehlers- Danlos-like phenotype. Radiologic features included mild to moderate platyspondyly, mild to moderate osteopenia of the spine, small ileum, flat proximal femoral epiphyses, short, wide femoral necks, and broad metaphyses (elbows, knees, wrists, and interphalangeal joints). Belongs to the ZIP transporter (TC 2.A.5) family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Membrane protein, integral; Membrane protein, multi-pass

Chromosomal Location of Human Ortholog: 11p11.2

Cellular Component: Golgi apparatus; perinuclear region of cytoplasm; integral to membrane; integral to Golgi membrane

Molecular Function: protein homodimerization activity; zinc ion transmembrane transporter activity

Biological Process: cellular zinc ion homeostasis

Disease: Spondylocheirodysplasia, Ehlers-danlos Syndrome-like