Rabbit NEUCRIN Polyclonal Antibody | anti-DRAXIN antibody

NEUCRIN Antibody

Cat. Num. AAA9414066

• Reactivity: Human, Mouse, Rat
• Applications: ELISA, Western Blot
• Purity: Affinity chromatography purified via peptide column
• Synonyms: NEUCRIN; Polyclonal Antibody; NEUCRIN Antibody; Draxin; dorsal repulsive axon guidance protein; anti-DRAXIN antibody

• Host: Rabbit
• Reactivity: Human, Mouse, Rat
• Clonality: Polyclonal
• Specificity: At least three isoforms of Neucrin are known to exist; this antibody will detect the two shorter isoforms. Neucrin antibody is predicted to not cross-react with RILP.
• Purity/Purification: Affinity chromatography purified via peptide column
• Form/Format: Supplied in PBS containing 0.02% sodium azide.
• Sequence Length: 349

• Applicable Applications for anti-DRAXIN antibody: ELISA (EIA), Western Blot (WB)
• Immunogen Type: Peptide
• Immunogen Description: Raised against a 17 amino acid peptide near the carboxy terminus of human Neucrin.
• Target Name: NEUCRIN
• Preparation and Storage: Can be stored at -20 degree C, stable for one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Western Blot (WB)

(Western blot analysis of Neucrin in rat cerebellum tissue lysate with Neucrin antibody at 1 ug/mL.)

Related Product Information for anti-DRAXIN antibody

Neucrin, also known as Draxin, is a repulsive guidance protein for the spinal cord and forebrain commissures. It is thought to act as an antagonist of canonical Wnt signaling by inhibiting the stabilization of cytosolic beta-catenin. Ectopically expressed neucrin inhibited growth or caused misrouting of chick spinal cord commissural axons in vivo while Neucrin-null mice showed defasciculation of spinal cord commissural axons and an absence of all forebrain commisures. Other experiments in mice have shown that olfactory bulb axonal outgrowth is inhibited by Neucrin, suggesting that Neucrin functions as an inhibitory guidance cue for olfactory bulb axons.

Product Categories/Family for anti-DRAXIN antibody

Total protein Ab

NCBI and Uniprot Product Information

• NCBI GI #: 209954741
• Molecular Weight: 38,650 Da
• NCBI Official Full Name: neucrin
• UniProt Protein Name: Draxin
• Protein Family: Draxin
• UniProt Gene Name: DRAXIN
• UniProt Entry Name: DRAXI_HUMAN

Uniprot Description

DRAXIN: Chemorepulsive axon guidance protein required for the development of spinal cord and forebrain commissures. Acts as a chemorepulsive guidance protein for commissural axons during development. Able to inhibit or repel neurite outgrowth from dorsal spinal cord. Inhibits the stabilization of cytosolic beta- catenin (CTNNB1) via its interaction with LRP6, thereby acting as an antagonist of Wnt signaling pathway. Belongs to the draxin family.

Protein type: Secreted; Secreted, signal peptide

Chromosomal Location of Human Ortholog: 1p36.22

Cellular Component: extracellular region

Biological Process: dorsal spinal cord development; axon guidance; Wnt receptor signaling pathway; forebrain development; commissural neuron differentiation in the spinal cord; negative regulation of neuron apoptosis; negative regulation of axon extension