Immunohistochemistry (IHC)
(Anti-C1orf187 / DRAXIN antibody IHC staining of human brain, cortex. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.)
Rabbit C1orf187 / DRAXIN Polyclonal Antibody | anti-C1orf187 / DRAXIN antibody
Anti-C1orf187 / DRAXIN Antibody (C-Terminus) IHC-plus
Gene Names
DRAXIN; UNQ3119; neucrin; AGPA3119; C1orf187
Reactivity
Mouse, Rat, Human
Applications
Immunohistochemistry, Immunofluorescence, Western Blot, ELISA
Purity
Immunoaffinity purified
Synonyms
C1orf187 / DRAXIN; Polyclonal Antibody; Anti-C1orf187 / DRAXIN Antibody (C-Terminus) IHC-plus; Rabbit Polyclonal to Human C1orf187 / DRAXIN; Human C1orf187 / DRAXIN; AGPA3119; UNQ3119; Neucrin; anti-C1orf187 / DRAXIN antibody
Host
Rabbit
Reactivity
Mouse, Rat, Human
Clonality
Polyclonal
Specificity
Human C1orf187 / Neucrin/ Draxin. At least three isoforms of Neucrin are known to exist; this antibody will detect the two shorter isoforms. Neucrin antibody is predicted to not cross-react with RILP.
Purity/Purification
Immunoaffinity purified
Form/Format
PBS, 0.02% sodium azide
Concentration
1 mg/ml (varies by lot)
Sequence Length
349
Applicable Applications for anti-C1orf187 / DRAXIN antibody
Immunohistochemistry (IHC) Paraffin, Immunofluorescence (IF), Western Blot (WB), ELISA (EIA)
Application Notes
IF (20 ug/ml)
IHC-P (5 ug/ml)
WB (1 ug/ml)
IHC-P (5 ug/ml)
WB (1 ug/ml)
Immunogen
C1orf187 / DRAXIN antibody was raised against a 17 amino acid peptide near the carboxy terminus of human Neucrin
Immunogen Description
A 17 amino acid peptide near the carboxy terminus of human Neucrin
Immunogen Type
Synthetic peptide
Antigen Modification
C-Terminus
Target Species
Human
Preparation and Storage
Short term 4 degree C
Long term aliquot and store at -20 degree C
Avoid freeze thaw cycles. Store undiluted.
Long term aliquot and store at -20 degree C
Avoid freeze thaw cycles. Store undiluted.
Immunohistochemistry (IHC)
(Anti-C1orf187 / DRAXIN antibody IHC staining of human brain, cortex. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.)
Immunohistochemistry (IHC)
(Anti-C1orf187 / DRAXIN antibody IHC staining of human brain, cortex. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.)
Immunofluorescence (IF)
(Immunofluorescence of NEUCRIN in mouse brain tissue with NEUCRIN antibody at 20 µg/mL.)
Immunofluorescence (IF)
(Immunofluorescence of NEUCRIN in mouse brain tissue with NEUCRIN antibody at 20 µg/mL.)
Western Blot (WB)
(Western blot analysis of Neucrin in rat cerebellum tissue lysate with Neucrin antibody at 1 ug/ml.)
Western Blot (WB)
(Western blot analysis of Neucrin in rat cerebellum tissue lysate with Neucrin antibody at 1 ug/ml.)
Related Product Information for anti-C1orf187 / DRAXIN antibody
DRAXIN Antibody, AGPA3119 Antibody, UNQ3119 Antibody, C1orf187 Antibody, Neucrin Antibody Description: Chemorepulsive axon guidance protein required for the development of spinal cord and forebrain commissures. Acts as a chemorepulsive guidance protein for commissural axons during development. Able to inhibit or repel neurite outgrowth from dorsal spinal cord. Inhibits the stabilization of cytosolic beta-catenin (CTNNB1) via its interaction with LRP6, thereby acting as an antagonist of Wnt signaling pathway.
NCBI and Uniprot Product Information
NCBI GI #
NCBI GeneID
Molecular Weight
38,650 Da
NCBI Official Full Name
Draxin
NCBI Official Synonym Full Names
dorsal inhibitory axon guidance protein
NCBI Official Symbol
DRAXIN
NCBI Official Synonym Symbols
UNQ3119; neucrin; AGPA3119; C1orf187
NCBI Protein Information
draxin
UniProt Protein Name
Draxin
UniProt Gene Name
DRAXIN
UniProt Entry Name
DRAXI_HUMAN
Uniprot Description
DRAXIN: Chemorepulsive axon guidance protein required for the development of spinal cord and forebrain commissures. Acts as a chemorepulsive guidance protein for commissural axons during development. Able to inhibit or repel neurite outgrowth from dorsal spinal cord. Inhibits the stabilization of cytosolic beta- catenin (CTNNB1) via its interaction with LRP6, thereby acting as an antagonist of Wnt signaling pathway. Belongs to the draxin family.
Protein type: Secreted; Secreted, signal peptide
Chromosomal Location of Human Ortholog: 1p36.22
Cellular Component: extracellular region
Molecular Function: protein binding
Biological Process: axon guidance; commissural neuron differentiation in the spinal cord; dorsal spinal cord development; forebrain development; negative regulation of axon extension; negative regulation of neuron apoptosis; Wnt receptor signaling pathway
Research Articles on C1orf187 / DRAXIN
Similar Products
Product Notes
The C1orf187 / DRAXIN draxin (Catalog #AAA249743) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The Anti-C1orf187 / DRAXIN Antibody (C-Terminus) IHC-plus reacts with Mouse, Rat, Human and may cross-react with other species as described in the data sheet. AAA Biotech's C1orf187 / DRAXIN can be used in a range of immunoassay formats including, but not limited to, Immunohistochemistry (IHC) Paraffin, Immunofluorescence (IF), Western Blot (WB), ELISA (EIA). IF (20 ug/ml) IHC-P (5 ug/ml) WB (1 ug/ml). Researchers should empirically determine the suitability of the C1orf187 / DRAXIN draxin for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "C1orf187 / DRAXIN, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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