Rabbit SLAIN1 Polyclonal Antibody | anti-SLAIN1 antibody

SLAIN1 Antibody

Cat. Num. AAA9408574

• Gene Names: MYBPC1; LCCS4; MYBPCC; MYBPCS
• Reactivity: Human, Mouse, Rat
• Applications: ELISA, Western Blot
• Purity: Affinity chromatography purified via peptide column
• Synonyms: SLAIN1; Polyclonal Antibody; SLAIN1 Antibody; Slain motif family 1; c13orf32; anti-SLAIN1 antibody

• Host: Rabbit
• Reactivity: Human, Mouse, Rat
• Clonality: Polyclonal
• Specificity: At least three isoforms of SLAIN1 are known to exist; this antibody will detect all three. SLAIN1 antibody is predicted not to cross-react with SLAIN2.
• Purity/Purification: Affinity chromatography purified via peptide column
• Form/Format: Supplied in PBS containing 0.02% sodium azide.
• Sequence Length: 1171

• Applicable Applications for anti-SLAIN1 antibody: ELISA (EIA), Western Blot (WB)
• Immunogen Type: Peptide
• Immunogen Description: Raised against an 15 amino acid peptide near the carboxy terminus of human SLAIN1.
• Target Name: SLAIN1
• Preparation and Storage: Can be stored at -20 degree C, stable for one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Western Blot (WB)

(Western blot analysis of SLAIN1 in A549 cell lysate with SLAIN1 antibody at 1 ug/mL in (A) the absence and (B) the presence of blocking peptide.)

Related Product Information for anti-SLAIN1 antibody

SLAIN1 is a novel stem cell protein that was identified by transciptional profiling of mouse and human embryonic stem cells (ESCs) and is expressed at the stem cell and epiblast stages. Unlike its more widely expressed homolog SLAIN2, SLAIN1 was found to be expressed in the epiblast, nervous system, tailbud and somites of the developing mouse embryo later experiments suggested that SLAIN1 may play a role in the development of the nervous system as well as in the morphogenesis of several embryonic structures.

Product Categories/Family for anti-SLAIN1 antibody

Total protein Ab

NCBI and Uniprot Product Information

• NCBI GI #: 45976288
• NCBI GeneID: 4604
• NCBI Accession #: NP_002456
• NCBI GenBank Nucleotide #: NM_002465.3
• Molecular Weight: 129,074 Da
• NCBI Official Full Name: myosin-binding protein C, slow-type isoform 1
• NCBI Official Synonym Full Names: myosin binding protein C, slow type
• NCBI Official Symbol: MYBPC1
• NCBI Official Synonym Symbols: LCCS4; MYBPCC; MYBPCS
• NCBI Protein Information: myosin-binding protein C, slow-type
• UniProt Protein Name: Myosin-binding protein C, slow-type
• Protein Family: SLAIN motif-containing protein
• UniProt Gene Name: MYBPC1
• UniProt Synonym Gene Names: MYBPCS; Slow MyBP-C
• UniProt Entry Name: MYPC1_HUMAN

NCBI Description

This gene encodes a member of the myosin-binding protein C family. Myosin-binding protein C family members are myosin-associated proteins found in the cross-bridge-bearing zone (C region) of A bands in striated muscle. The encoded protein is the slow skeletal muscle isoform of myosin-binding protein C and plays an important role in muscle contraction by recruiting muscle-type creatine kinase to myosin filaments. Mutations in this gene are associated with distal arthrogryposis type I. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Dec 2011]

Uniprot Description

MYBPC1: Thick filament-associated protein located in the crossbridge region of vertebrate striated muscle a bands. In vitro it binds MHC, F-actin and native thin filaments, and modifies the activity of actin-activated myosin ATPase. It may modulate muscle contraction or may play a more structural role. Defects in MYBPC1 are the cause of arthrogryposis, distal, type 1B (DA1B). A form of distal arthrogryposis, a disease characterized by congenital joint contractures that mainly involve two or more distal parts of the limbs, in the absence of a primary neurological or muscle disease. Distal arthrogryposis type 1 is characterized largely by camptodactyly and clubfoot. Hypoplasia and/or absence of some interphalangeal creases is common. The shoulders and hips are less frequently affected. Defects in MYBPC1 may be a cause of autosomal recessive lethal congenital contractural syndrome (LCCS), a severe, neonatally lethal form of arthrogryposis. Belongs to the immunoglobulin superfamily. MyBP family. 3 isoforms of the human protein are produced by alternative splicing.

Protein type: Actin-binding; Myosin-binding

Chromosomal Location of Human Ortholog: 12q23.2

Cellular Component: cytosol; myofibril

Molecular Function: actin binding; protein binding; structural constituent of muscle; titin binding

Biological Process: cell adhesion; muscle filament sliding

Disease: Arthrogryposis, Distal, Type 1b; Lethal Congenital Contracture Syndrome 4