Rabbit IGFL2 Polyclonal Antibody | anti-IGFL2 antibody

IGFL2 Polyclonal Antibody

Cat. Num. AAA3006820

• Reactivity: Human, Mouse, Rat
• Applications: Western Blot
• Purity: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is >95% (by SDS-PAGE).
• Synonyms: IGFL2; Polyclonal Antibody; IGFL2 Polyclonal Antibody; Insulin growth factor-like family member 2; anti-IGFL2 antibody

• Host: Rabbit
• Reactivity: Human, Mouse, Rat
• Clonality: Polyclonal
• Isotype: IgG
• Specificity: IGFL2 polyclonal antibody detects endogenous levels of IGFL2 protein.
• Purity/Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is >95% (by SDS-PAGE).
• Form/Format: Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2
• Sequence Length: 130

• Applicable Applications for anti-IGFL2 antibody: Western Blot (WB)
• Application Notes: WB: 1:500-1:1000
• Immunogen: A synthetic peptide corresponding to residues in Human IGFL2.
• Preparation and Storage: Store at 4 degree C short term.; Aliquot and store at -20 degree C long term.; Avoid freeze-thaw cycles.

Western Blot (WB)

(Western Blot (WB) analysis of IGFL2 polyclonal antibody at 1:500 dilutionLane1:NIH-3T3 whole cell lysateLane2:H9C2 whole cell lysateLane3:Jurkat whole cell lysate)

Related Product Information for anti-IGFL2 antibody

The insulin gene family, comprised of insulin, relaxin and insulin-like growth factors I and II (IGF-I and IGF-II), represents a group of structurally related polypeptides whose biological functions have diverged. The IGFs, or somato-medins, constitute a class of polypeptides that have a key role in pre-adolescent mammalian growth. IGF-I and -II are critical regulators of cell proliferation and differentiation. Most of the growth promoting properties of both ligands are mediated by the IGF-I receptor (IGF-IR). IGF- I and -II, respectively known as somatomedin C and somatomedin A, are single chain polypeptides which share an amino acid sequence homology of about 47% with insulin. IGF-I expression is regulated by growth hormone and mediates postnatal growth, while IGF-II is induced by placental lactogen during prenatal development. IGF-II is a fetal growth factor, influenced by placental lactogen and abundantly expressed by placental trophoblasts. IGF-II and IGF-binding protein 1 (IGFBP1) gene variants are associated with overfeeding-induced metabolic changes. The human IGF-II gene maps to chromosome 11p15.5, encoding a 180 amino acid protein which is the precursor to IGF-II.

NCBI and Uniprot Product Information

• NCBI GI #: 205361122
• NCBI Accession #: NP_001002915.2
• NCBI GenBank Nucleotide #: NP_001002915.2
• UniProt Accession #: Q6UWQ7
• Molecular Weight: ~ 13kDa
• NCBI Official Full Name: insulin growth factor-like family member 2 isoform a
• UniProt Protein Name: Insulin growth factor-like family member 2
• Protein Family: Insulin growth factor-like family
• UniProt Gene Name: IGFL2
• UniProt Entry Name: IGFL2_HUMAN

Uniprot Description

IGFL2: Potential ligand of the IGFLR1 cell membrane receptor. Belongs to the IGFL family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Secreted, signal peptide; Secreted

Chromosomal Location of Human Ortholog: 19q13.32

Cellular Component: extracellular region