Rabbit ALS Polyclonal Antibody | anti-ALS antibody

ALS Polyclonal Antibody

Cat. Num. AAA3005670

• Gene Names: IGFALS; ALS; ACLSD
• Reactivity: Human, Mouse, Rat
• Applications: Western Blot
• Purity: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is >95% (by SDS-PAGE).
• Synonyms: ALS; Polyclonal Antibody; ALS Polyclonal Antibody; Insulin-like growth factor-binding protein complex acid labile subunit; IGFALS; anti-ALS antibody

• Host: Rabbit
• Reactivity: Human, Mouse, Rat
• Clonality: Polyclonal
• Isotype: IgG
• Specificity: ALS polyclonal antibody detects endogenous levels of ALS protein.
• Purity/Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is >95% (by SDS-PAGE).
• Form/Format: Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2
• Sequence Length: 643

• Applicable Applications for anti-ALS antibody: Western Blot (WB)
• Application Notes: WB: 1:500-1:1000
• Immunogen: Synthetic peptide, corresponding to amino acids 177-222 of Human ALS.
• Preparation and Storage: Store at 4 degree C short term.; Aliquot and store at -20 degree C long term.; Avoid freeze-thaw cycles.

Western Blot (WB)

(Western Blot (WB) analysis of ALS polyclonal antibody at 1:500 dilutionLane1:HEK293T cell lysateLane2:Mouse liver tissue lysateLane3:Rat kidney tissue lysate)

Related Product Information for anti-ALS antibody

The Insulin-like growth factor binding proteins, or IGFBPs, are a family of seven proteins that have co-evolved with the IGFs. IGFBPs serve as shuttle molecules for both IGF-I and IGF-II and confer a level of regulation to the IGF signaling system by influencing the bio-availability, concentration and distribution of IGFs in the extracellular environment. In human circulation, the IGF-binging protein complex requires ALS (IGFBP acid-labile subunit), an extracellular protein involved in receptor-ligand binding and cell adhesion. ALS, detected primarily in plasma, is involved in protein-protein interactions that result in the formation of protein complexes.

NCBI and Uniprot Product Information

• NCBI GI #: 225579152
• NCBI GeneID: 3483
• NCBI Accession #: NP_001139478.1
• NCBI GenBank Nucleotide #: NP_001139478.1
• UniProt Accession #: P35858
• Molecular Weight: ~ 66kDa
• NCBI Official Full Name: insulin-like growth factor-binding protein complex acid labile subunit isoform 1
• NCBI Official Synonym Full Names: insulin like growth factor binding protein acid labile subunit
• NCBI Official Symbol: IGFALS
• NCBI Official Synonym Symbols: ALS; ACLSD
• NCBI Protein Information: insulin-like growth factor-binding protein complex acid labile subunit
• UniProt Protein Name: Insulin-like growth factor-binding protein complex acid labile subunit
• Protein Family: Alsin
• UniProt Gene Name: IGFALS
• UniProt Synonym Gene Names: ALS; ALS
• UniProt Entry Name: ALS_HUMAN

NCBI Description

The protein encoded by this gene is a serum protein that binds insulin-like growth factors, increasing their half-life and their vascular localization. Production of the encoded protein, which contains twenty leucine-rich repeats, is stimulated by growth hormone. Defects in this gene are a cause of acid-labile subunit deficiency, which maifests itself in a delayed and slow puberty. Three transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Mar 2009]

Uniprot Description

IGFALS: Involved in protein-protein interactions that result in protein complexes, receptor-ligand binding or cell adhesion.

Protein type: Cell adhesion; Secreted, signal peptide; Secreted

Chromosomal Location of Human Ortholog: 16p13.3

Cellular Component: nucleoplasm; extracellular space; extracellular region

Molecular Function: insulin-like growth factor binding

Biological Process: cellular protein metabolic process; signal transduction; cell adhesion

Disease: Acid-labile Subunit Deficiency