Immunohistochemistry (IHC)
(Immunochemical staining of human ZDHHC12 in human brain with rabbit polyclonal antibody at 1:500 dilution, formalin-fixed paraffin embedded sections.)
Rabbit anti-Human ZDHHC12 Polyclonal Antibody | anti-ZDHHC12 antibody
Anti-ZDHHC12 Antibody, Rabbit Polyclonal
Reactivity
Human
Applications
Immunohistochemistry
Purity
Protein A & Antigen Affinity
Synonyms
ZDHHC12; Polyclonal Antibody; Anti-ZDHHC12 Antibody; Rabbit Polyclonal; ZDHHC12 Antibody; Rabbit PAb; Antigen Affinity Purified; zinc finger; DHHC-type containing 12; Anti-RP11-545E17.12-002 Antibody; Anti-ZNF400 Antibody; anti-ZDHHC12 antibody
Host
Rabbit
Reactivity
Human
Clonality
Polyclonal
Isotype
Rabbit IgG
Specificity
Human ZDHHC12
Purity/Purification
Protein A & Antigen Affinity
Form/Format
Liquid; PBS, pH7.0 with 0.03% Proclin300
Applicable Applications for anti-ZDHHC12 antibody
Immunohistochemistry-Paraffin (IHC-P)
Application Notes
IHC-P: 1:200-1:1000
Immunogen
E Coli-derived Human ZDHHC12 fragment
Conjugation
Unconjugated
Preparation
Produced in rabbits immunized with E Coli-derived Human ZDHHC12 fragment, and purified by antigen affinity chromatography.
Preparation and Storage
This antibody can be stored at 2-8 degree C for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20 degree C to -80 degree C. Avoid repeated freeze-thaw cycles.
Immunohistochemistry (IHC)
(Immunochemical staining of human ZDHHC12 in human brain with rabbit polyclonal antibody at 1:500 dilution, formalin-fixed paraffin embedded sections.)
Immunohistochemistry (IHC)
(Immunochemical staining of human ZDHHC12 in human brain with rabbit polyclonal antibody at 1:500 dilution, formalin-fixed paraffin embedded sections.)
Immunohistochemistry (IHC)
(Immunochemical staining of human ZDHHC12 in human liver with rabbit polyclonal antibody at 1:500 dilution, formalin-fixed paraffin embedded sections.)
Immunohistochemistry (IHC)
(Immunochemical staining of human ZDHHC12 in human liver with rabbit polyclonal antibody at 1:500 dilution, formalin-fixed paraffin embedded sections.)
Related Product Information for anti-ZDHHC12 antibody
ZDHHC12 (Zinc Finger DHHC-Type Palmitoyltransferase 12) is a Protein Coding gene. The ZDHHC12 gene, located on 9q34.11, is conserved in chimpanzee, dog, cow, mouse, rat, chicken, zebrafish, and frog. ZDHHC12 belongs to the DHHC palmitoyltransferase family. 3 alternatively spliced human isoforms have been reported. ZDHHC12 is widely expressed in the colon, stomach, and other tissues. ZDHHC12-mediated S-palmitoylation promotes the cell membrane localization of claudin-3 (CLDN3) and maintains its stability in ovarian cancer cells, contributing to the oncoprotein function of CLDN3. Targeting ZDHHC12-mediated CLDN3 S-palmitoylation might be a potential strategy for ovarian cancer therapy. 225 organisms have orthologs with the human gene ZDHHC12.
References
Yuan M, et al. (2020) Zdhhc12-mediated claudin-3 s-palmitoylation determines ovarian cancer progression. Acta Pharm Sin B 10 (8): 1426-1439.Ohno Y, et al. (2006) Intracellular localization and tissue-specific distribution of human and yeast dhhc cysteine-rich domain-containing proteins. Biochim Biophys Acta 1761 (4): 474-483.Dejanovic B, et al. (2014) Palmitoylation of gephyrin controls receptor clustering and plasticity of gabaergic synapses. PLoS Biol 12 (7): e1001908.
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Product Notes
The ZDHHC12 (Catalog #AAA8110179) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The Anti-ZDHHC12 Antibody, Rabbit Polyclonal reacts with Human and may cross-react with other species as described in the data sheet. AAA Biotech's ZDHHC12 can be used in a range of immunoassay formats including, but not limited to, Immunohistochemistry-Paraffin (IHC-P). IHC-P: 1:200-1:1000. Researchers should empirically determine the suitability of the ZDHHC12 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "ZDHHC12, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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