Rabbit CD290 Polyclonal Antibody | anti-CD290 antibody

RABBIT ANTI HUMAN CD290

Cat. Num. AAA221823

• Gene Names: TLR10; CD290
• Applications: Western Blot
• Synonyms: CD290; Polyclonal Antibody; RABBIT ANTI HUMAN CD290; anti-CD290 antibody

• Host: Rabbit
• Clonality: Polyclonal
• Isotype: IgG
• Form/Format: Purified; Purified IgG - liquid
• Concentration: IgG concentration 1 mg/ml (varies by lot)
• Sequence Length: 811

• Applicable Applications for anti-CD290 antibody: Western Blot (WB)
• Application Notes: Western Blotting: Minimum Dilution: 0.5ug/ml; Maximum Dilution: 1.0ug/ml
• Perservative Stabilisers: 0.02% Sodium Azide
• Immunogen: Synthetic peptide corresponding to a 14 amino acid sequence within human CD290.; Buffer Solution
• Antiserum Preparation: Antisera to human CD290 were raised by repeated immunisations of rabbits with highly purified antigen. Purified IgG prepared by ion exchange chromatography.
• Target Species: Human
• Preparation and Storage: Store at 4 degree C or at -20 degree C if preferred. Storage in frost-free freezers is not recommended. This product should be stored undiluted. Avoid repeated freezing and thawing as this may denature the antibody. Should this product contain a precipitate we recommend microcentrifugation before use.; Shelf Life: 18 months from date of despatch.

Testing Data #1

(Western blot analysis of human lymph node lysate probed with Rabbit anti Human TLR10 (MBS221823) at 0.5(A) and 1(B) ug/ml)

Related Product Information for anti-CD290 antibody

Rabbit anti Human CD290 antibody recognizes human CD290, otherwise known as Toll-like receptor 10 (TLR10), a member of the Toll-like receptor family principally expressed in peripheral B lymphocytes and plasmacytoid dendritic cells. CD290 has been shown to interact with MyD88 adaptor protein, and is thought to play a role in the activation of signalling cascades linking the innate and adaptive immune response to pathogens.

NCBI and Uniprot Product Information

• NCBI GI #: 62865621
• NCBI GeneID: 81793
• NCBI Accession #: NP_001017388.1
• NCBI GenBank Nucleotide #: NM_001017388.2
• UniProt Accession #: Q9BXR5; Q32MI7; Q32MI8; Q5FWG4; Q6UXL3; A8K7L1; B3Y668; D1CS21; D1CS22
• Molecular Weight: 94,564 Da
• NCBI Official Full Name: toll-like receptor 10 isoform a
• NCBI Official Synonym Full Names: toll-like receptor 10
• NCBI Official Symbol: TLR10
• NCBI Official Synonym Symbols: CD290
• NCBI Protein Information: toll-like receptor 10
• UniProt Protein Name: Toll-like receptor 10
• UniProt Gene Name: TLR10
• UniProt Entry Name: TLR10_HUMAN

NCBI Description

The protein encoded by this gene is a member of the Toll-like receptor (TLR) family which plays a fundamental role in pathogen recognition and activation of innate immunity. TLRs are highly conserved from Drosophila to humans and share structural and functional similarities. They recognize pathogen-associated molecular patterns (PAMPs) that are expressed on infectious agents, and mediate the production of cytokines necessary for the development of effective immunity. The various TLRs exhibit different patterns of expression. This gene is most highly expressed in lymphoid tissues such as spleen, lymph node, thymus, and tonsil. Multiple alternatively spliced transcript variants which encode different protein isoforms have been found for this gene. [provided by RefSeq, Aug 2010]

Uniprot Description

TLR10: Participates in the innate immune response to microbial agents. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Belongs to the Toll-like receptor family.

Protein type: Membrane protein, integral; Receptor, misc.

Chromosomal Location of Human Ortholog: 4p14

Cellular Component: membrane; integral to membrane; plasma membrane

Molecular Function: transmembrane receptor activity

Biological Process: toll-like receptor 5 signaling pathway; MyD88-dependent toll-like receptor signaling pathway; regulation of cytokine secretion; toll-like receptor signaling pathway; innate immune response; immune response; inflammatory response; positive regulation of inflammatory response; toll-like receptor 10 signaling pathway