Mouse anti-Human TLR10 Monoclonal Antibody | anti-TLR10 antibody

TLR10 Monoclonal Antibody

Cat. Num. AAA668030

• Gene Names: TLR10; CD290
• Reactivity: Human
• Applications: Western Blot
• Purity: Protein G Chromatography
• Synonyms: TLR10; Monoclonal Antibody; TLR10 Monoclonal Antibody; anti-TLR10 antibody

• Host: Mouse
• Reactivity: Human
• Clonality: Monoclonal
• Isotype: Mouse IgG2a, Kappa
• Clone Number: ABM3C85
• Purity/Purification: Protein G Chromatography
• Form/Format: Purified; 25 ug in 50 ul/100 ug in 200 ul PBS containing 0.05% BSA and 0.05% sodium azide. Sodium azide is highly toxic.
• Sequence Length: 811

• Applicable Applications for anti-TLR10 antibody: Western Blot (WB)
• Application Notes: Western blot analysis: 2-4 ug/ml
• Antigen: TLR10
• Immunogen: A partial length recombinant TLR10 protein (Amino acid sequence 100-369 ) was used as the immunogen for this antibody.
• Preparation and Storage: Store antibody at 4 degree C, stable for 6 months. For long-term storage, store at -20 degree C. Avoid repeated freeze and thaw cycles. Expire 1 year from date of purchase.

Western Blot (WB)

(Expression analysis of TLR10. Anti- TLR10 antibody (Clone: ABM3C85) was used at 2 µg/ml on human ovary lysate.)

Flow Cytometry (FC/FACS)

(Intracellular flow analysis of TLR10 in human PBMC (monocytes) using 2.0 µg/10^6 cells of TLR10 antibody (Clone: ABM3C85). Green represents isotype control; red represents anti-TLR10 antibody. Goat anti-mouse PE conjugate was used as secondary.)

Related Product Information for anti-TLR10 antibody

TLR10 (Toll-Like Receptor10) is an orphan member of the TLR family and is the only pattern-recognition receptor without known ligand specificity and biological function. This protein plays a role in innate immune responses following viral infection. Influenza virus infection increased TLR10 expression and TLR10 contributed to innate immune sensing of viral infection leading to cytokine induction, including proinflammatory cytokines and interferons. Blocking TLR10 by antagonistic antibodies enhanced proinflammatory cytokine production, including IL-1Beta, specifically after exposure to TLR2 ligands. TLR10 is in a locus that also contains TLR1 and TLR6, two receptors known to function as coreceptors for TLR2. TLR10 is predominantly expressed in tissues rich in immune cells, such as spleen, lymph node, thymus, tonsil, and lung. Expression of TLR10 can be induced in B cells, dendritic cells, eosinophils, and neutrophils, as well as on nonimmune cells, such as trophoblasts.

Product Categories/Family for anti-TLR10 antibody

TLR

NCBI and Uniprot Product Information

• NCBI GI #: 62865621
• NCBI GeneID: 81793
• NCBI Accession #: NP_001017388.1
• NCBI GenBank Nucleotide #: NM_001017388.2
• UniProt Accession #: Q9BXR5; Q32MI7; Q32MI8; Q5FWG4; Q6UXL3; A8K7L1; B3Y668; D1CS21; D1CS22
• NCBI Official Full Name: toll-like receptor 10 isoform a
• NCBI Official Synonym Full Names: toll-like receptor 10
• NCBI Official Symbol: TLR10
• NCBI Official Synonym Symbols: CD290
• NCBI Protein Information: toll-like receptor 10
• UniProt Protein Name: Toll-like receptor 10
• Protein Family: Toll-like receptor
• UniProt Gene Name: TLR10
• UniProt Entry Name: TLR10_HUMAN

NCBI Description

The protein encoded by this gene is a member of the Toll-like receptor (TLR) family which plays a fundamental role in pathogen recognition and activation of innate immunity. TLRs are highly conserved from Drosophila to humans and share structural and functional similarities. They recognize pathogen-associated molecular patterns (PAMPs) that are expressed on infectious agents, and mediate the production of cytokines necessary for the development of effective immunity. The various TLRs exhibit different patterns of expression. This gene is most highly expressed in lymphoid tissues such as spleen, lymph node, thymus, and tonsil. Multiple alternatively spliced transcript variants which encode different protein isoforms have been found for this gene. [provided by RefSeq, Aug 2010]

Uniprot Description

TLR10: Participates in the innate immune response to microbial agents. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Belongs to the Toll-like receptor family.

Protein type: Receptor, misc.; Membrane protein, integral

Chromosomal Location of Human Ortholog: 4p14

Cellular Component: membrane; plasma membrane; integral to membrane

Molecular Function: transmembrane receptor activity

Biological Process: toll-like receptor 5 signaling pathway; MyD88-dependent toll-like receptor signaling pathway; regulation of cytokine secretion; toll-like receptor signaling pathway; innate immune response; immune response; inflammatory response; positive regulation of inflammatory response; toll-like receptor 10 signaling pathway