Rabbit anti-Human TLR10 Polyclonal Antibody | anti-TLR10 antibody

TLR10 Antibody

Cat. Num. AAA9406898

• Gene Names: TLR10; CD290
• Reactivity: Human
• Applications: ELISA, Western Blot
• Purity: Ion exchange chromatography purified
• Synonyms: TLR10; Polyclonal Antibody; TLR10 Antibody; CD290; anti-TLR10 antibody

• Host: Rabbit
• Reactivity: Human
• Clonality: Polyclonal
• Purity/Purification: Ion exchange chromatography purified
• Form/Format: Supplied in PBS containing 0.02% sodium azide.
• Sequence Length: 811

• Applicable Applications for anti-TLR10 antibody: ELISA (EIA), Western Blot (WB)
• Immunogen Type: Peptide
• Immunogen Description: Raised against a peptide corresponding to 14 amino acids near the middle of human TLR10.
• Target Name: TLR10
• Preparation and Storage: Can be stored at -20 degree C, stable for one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Western Blot (WB)

(Western blot analysis of TLR10 in human lymph node cell lysates with TLR10 antibody (IN) at (A) 0.5 and (B) 1 ug/mL.)

Related Product Information for anti-TLR10 antibody

Toll-like receptors (TLRs) are signaling molecules that recognize different microbial products during infection and serve as an important link between the innate and adaptive immune responses. These proteins act through adaptor molecules such as MyD88 and TIRAP to activate various kinases and transcription factors. TLR10 is highly homologous to TLRs 1 and 6 and is most highly expressed in lymphoid tissues. Most recently genetic variation in TLR10 has been associated with contributing to asthma risk. It should be noted that TLR10 exists in mice only as a pseudogene.

Product Categories/Family for anti-TLR10 antibody

Total protein Ab

NCBI and Uniprot Product Information

• NCBI GI #: 37181720
• NCBI GeneID: 81793
• Molecular Weight: 94,564 Da
• NCBI Official Full Name: TLR10
• NCBI Official Synonym Full Names: toll-like receptor 10
• NCBI Official Symbol: TLR10
• NCBI Official Synonym Symbols: CD290
• NCBI Protein Information: toll-like receptor 10
• UniProt Protein Name: Toll-like receptor 10
• Protein Family: Toll-like receptor
• UniProt Gene Name: TLR10
• UniProt Entry Name: TLR10_HUMAN

NCBI Description

The protein encoded by this gene is a member of the Toll-like receptor (TLR) family which plays a fundamental role in pathogen recognition and activation of innate immunity. TLRs are highly conserved from Drosophila to humans and share structural and functional similarities. They recognize pathogen-associated molecular patterns (PAMPs) that are expressed on infectious agents, and mediate the production of cytokines necessary for the development of effective immunity. The various TLRs exhibit different patterns of expression. This gene is most highly expressed in lymphoid tissues such as spleen, lymph node, thymus, and tonsil. Multiple alternatively spliced transcript variants which encode different protein isoforms have been found for this gene. [provided by RefSeq, Aug 2010]

Uniprot Description

TLR10: Participates in the innate immune response to microbial agents. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Belongs to the Toll-like receptor family.

Protein type: Membrane protein, integral; Receptor, misc.

Chromosomal Location of Human Ortholog: 4p14

Cellular Component: membrane; integral to membrane; plasma membrane

Molecular Function: transmembrane receptor activity

Biological Process: toll-like receptor 5 signaling pathway; MyD88-dependent toll-like receptor signaling pathway; regulation of cytokine secretion; toll-like receptor signaling pathway; innate immune response; immune response; inflammatory response; positive regulation of inflammatory response; toll-like receptor 10 signaling pathway