Rabbit Adenovirus-9 E4 Orf1 Polyclonal Antibody | anti-E4 antibody

Adenovirus-9 E4 Orf1 Antibody

Cat. Num. AAA150451

• Reactivity: Virus
• Applications: ELISA
• Purity: Adenovirus-9 E4 Orf1 Antibody is affinity chromatography purified via peptide column.
• Synonyms: Adenovirus-9 E4 Orf1; Polyclonal Antibody; Adenovirus-9 E4 Orf1 Antibody; E4-ORF1; ORF1; anti-E4 antibody

• Host: Rabbit
• Reactivity: Virus
• Clonality: Polyclonal
• Isotype: IgG
• Purity/Purification: Adenovirus-9 E4 Orf1 Antibody is affinity chromatography purified via peptide column.
• Form/Format: Liquid
• Concentration: 1 mg/mL (varies by lot)
• Sequence Length: 125

• Applicable Applications for anti-E4 antibody: ELISA (EIA)
• Application Notes: Ad-9 E4 Orf1 antibody can detect 10ng Ad-9 E4 Orf1 peptide in ELISA at 1 ug/mL.; Optimal dilutions for each application to be determined by the researcher
• Conjugate: Unconjugated
• Immunogen: Ad-9 E4 Orf1 antibody was raised against a 16 amino acid synthetic peptide near the carboxy terminus of the Ad-9 E4 Orf1.; The immunogen is located within the last 50 amino acids of Adenovirus-9 E4 Orf1
• Buffer: Adenovirus-9 E4 Orf1 Antibody is supplied in PBS containing 0.02% sodium azide.
• Preparation and Storage: Adenovirus-9 E4 Orf1 antibody can be stored at 4 degree C for three months and -20 degree C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Related Product Information for anti-E4 antibody

Adenovirus-9 E4 Orf1 Antibody: The many different serotypes of human adenoviruses (Ad) are divided into six subgroups, of which all Ad subgroup A and B and two subgroup D Ads can elicit tumors in infected rodents. Unlike the Ads from subgroup A and B, the ones from subgroup D, Ad9 and Ad10 elicit estrogen-dependent mammary tumors as opposed to undifferentiated sarcomas. In the case of Ad9, its tumorigenicity is dependent on the product of the open reading frame (ORF) 1 of the early region 4 (E4). The tumorigenic potential of Ad9 E4 Orf1 depends on a carboxyl-terminal PDZ domain-binding motif that mediates interactions with several different membrane-associated cellular proteins such as MUPP1, PATJ, MAGI-1, ZO-2 and Dlg1. It has been suggested that Ad9 E4 Orf1 may have evolved from an ancestral cellular dUTP pyrophosphatase.

NCBI and Uniprot Product Information

• NCBI GI #: 62510674
• NCBI GeneID: 6386282
• UniProt Accession #: P89079
• NCBI Official Full Name: E4-ORF1
• NCBI Official Symbol: E4
• NCBI Protein Information: control protein E4orf6/7; control protein E4 34K; control protein E4orf4; control protein E4orf3; control protein E4orf2; control protein E4orf1
• UniProt Protein Name: E4-ORF1
• Protein Family: E4-ORF1
• UniProt Gene Name: E4
• UniProt Entry Name: E4OR1_ADE09

Uniprot Description

Plays a key role in virus oncogenecity in animals. Binds and sequesters human MUPP1/MPDZ protein in the cytoplasm, preventing it from playing a role in cellular proliferation regulation. Induces cell transformation, probably by inactivating MPDZ protein.