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Western Blot (WB)
(Western blot analysis of LRRC26 in human prostate tissue lysate with LRRC26 antibody at 0.5 μg/ml in (A) the absence and (B) the presence of blocking peptide.)
Rabbit anti-Human LRRC26 Polyclonal Antibody | anti-LRRC26 antibody
LRRC26 Antibody
Gene Names
LRRC26; CAPC; bA350O14.10
Reactivity
Human
Applications
ELISA, Immunohistochemistry, Western Blot
Purity
LRRC26 antibody is affinity chromatography purified via peptide column.
Synonyms
LRRC26; Polyclonal Antibody; LRRC26 Antibody; CAPC; bA350O14.10; Leucine-rich repeat-containing protein 26; BK channel auxiliary gamma subunit LRRC26; leucine rich repeat containing 26; anti-LRRC26 antibody
Host
Rabbit
Reactivity
Human
Clonality
Polyclonal
Isotype
IgG
Specificity
LRRC26 antibody is human specific.
Purity/Purification
LRRC26 antibody is affinity chromatography purified via peptide column.
Form/Format
Liquid
Concentration
1 mg/mL (varies by lot)
Sequence Length
334
Applicable Applications for anti-LRRC26 antibody
ELISA, IHC-P, WB
Application Notes
LRRC26 antibody can be used for detection of LRRC26 by Western blot at 0.5 - 1 ug/ml. Antibody can also be used for immunohistochemistry starting at 2.5 ug/mL.
Optimal dilutions for each application to be determined by the researcher.
Positive Control:
1) Cat. No. MBS151661 - Human Prostate Tissue Lysate
2) Cat. No. MBS151729 - Jurkat Cell Lysate
Optimal dilutions for each application to be determined by the researcher.
Positive Control:
1) Cat. No. MBS151661 - Human Prostate Tissue Lysate
2) Cat. No. MBS151729 - Jurkat Cell Lysate
Conjugate
Unconjugated
Immunogen
LRRC26 antibody was raised against an 18 amino acid peptide near the carboxy terminus of human LRRC26.
The immunogen is located within the last 50 amino acids of LRRC26.
The immunogen is located within the last 50 amino acids of LRRC26.
Buffer
LRRC26 antibody is supplied in PBS containing 0.02% sodium azide.
Preparation and Storage
LRRC26 antibody can be stored at 4 degree C for three months and -20 degree C, stable for up to one year.
Western Blot (WB)
(Western blot analysis of LRRC26 in human prostate tissue lysate with LRRC26 antibody at 0.5 μg/ml in (A) the absence and (B) the presence of blocking peptide.)
Western Blot (WB)
(Western blot analysis of LRRC26 in human prostate tissue lysate with LRRC26 antibody at 0.5 μg/ml in (A) the absence and (B) the presence of blocking peptide.)
Immunohistochemistry (IHC)
(Immunohistochemistry of LRRC26 in human prostate tissue with LRRC26 antibody at 2.5 μg/mL.)
Immunohistochemistry (IHC)
(Immunohistochemistry of LRRC26 in human prostate tissue with LRRC26 antibody at 2.5 μg/mL.)
Immunohistochemistry (IHC)
(Immunohistochemistry of LRRC26 in human prostate tissue with LRRC26 antibody at 2.5 μg/ml.)
Immunohistochemistry (IHC)
(Immunohistochemistry of LRRC26 in human prostate tissue with LRRC26 antibody at 2.5 μg/ml.)
Western Blot (WB)
(Western blot analysis of LRRC26 in Jurkat cell lysate with LRRC26 antibody at 0.5 μg/ml in (A) the absence and (B) the presence of blocking peptide.)
Western Blot (WB)
(Western blot analysis of LRRC26 in Jurkat cell lysate with LRRC26 antibody at 0.5 μg/ml in (A) the absence and (B) the presence of blocking peptide.)
Immunofluorescence (IF)
(Immunofluorescence of LRRC26 in human prostate tissue with LRRC26 Antibody at 20 μg/mL.)
Immunofluorescence (IF)
(Immunofluorescence of LRRC26 in human prostate tissue with LRRC26 Antibody at 20 μg/mL.)
Related Product Information for anti-LRRC26 antibody
The LRRC26 protein was initially identified as a cytokeratin-associated protein whose expression was elevated in multiple cancer cell lines and cancer specimens as well in normal prostate and salivary gland tissues (1). LRRC26 was later found to negatively regulate the NF-kappaB activation and suppresses tumor growth and metastasis (2). LRRC26 can also act to selectively alter the efficacy of large conductance calcium-activated K (BK) channels (3).
NCBI and Uniprot Product Information
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
Molecular Weight
Predicted: 37 kDa
Observed: 48 kDa
Observed: 48 kDa
NCBI Official Full Name
leucine-rich repeat-containing protein 26
NCBI Official Synonym Full Names
leucine rich repeat containing 26
NCBI Official Symbol
LRRC26
NCBI Official Synonym Symbols
CAPC; bA350O14.10
NCBI Protein Information
leucine-rich repeat-containing protein 26; cytokeratin associated protein; cytokeratin-associated protein in cancer; BK channel auxiliary gamma subunit LRRC26; BK channel auxilliary gamma subunit LRRC26
UniProt Protein Name
Leucine-rich repeat-containing protein 26
Protein Family
UniProt Gene Name
LRRC26
UniProt Synonym Gene Names
CAPC
UniProt Entry Name
LRC26_HUMAN
Uniprot Description
LRRC26: Auxiliary protein of the large-conductance, voltage and calcium-activated potassium channel (BK alpha). Required for the conversion of BK alpha channels from a high-voltage to a low- voltage activated channel type in non-excitable cells. These are characterized by negative membrane voltages and constant low levels of calcium. 2 isoforms of the human protein are produced by alternative splicing.
Protein type: Membrane protein, integral
Chromosomal Location of Human Ortholog: 9q34.3
Cellular Component: voltage-gated potassium channel complex; cytoskeleton; cytoplasm
Molecular Function: protein binding; potassium channel regulator activity
Biological Process: ion transport
Research Articles on LRRC26
Similar Products
Product Notes
The LRRC26 lrrc26 (Catalog #AAA153399) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The LRRC26 Antibody reacts with Human and may cross-react with other species as described in the data sheet. AAA Biotech's LRRC26 can be used in a range of immunoassay formats including, but not limited to, ELISA, IHC-P, WB. LRRC26 antibody can be used for detection of LRRC26 by Western blot at 0.5 - 1 ug/ml. Antibody can also be used for immunohistochemistry starting at 2.5 ug/mL. Optimal dilutions for each application to be determined by the researcher. Positive Control: 1) Cat. No. MBS151661 - Human Prostate Tissue Lysate 2) Cat. No. MBS151729 - Jurkat Cell Lysate. Researchers should empirically determine the suitability of the LRRC26 lrrc26 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "LRRC26, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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