Testing Data
AOPP-Human Serum Albumin (AOPP-HSA) Native Protein
AOPP-Human Serum Albumin (AOPP-HSA)
Synonyms
AOPP-Human Serum Albumin (AOPP-HSA); AOPP-Human Serum Albumin (AOPP-HSA) native protein
Application Notes
AOPP-HSA Conjugate is a simple, reproducible, and consistent control for assays measuring the detection of advanced oxidation protein products in plasma, lysates, and tissue homogenates. The AOPP-HSA concentration was determined from a Chloramine equivalence standard .
Quantity
50 uL of 7.5 mg/mL AOPP-HSA in 1X PBS at 0.136 umol AOPP/mg proteins.
Preparation and Storage
-20 degree C. Shelf Life: 1 year from receipt under proper storage conditions; aliquot to avoid multiple freeze thaw cycles
Testing Data
Testing Data
Related Product Information for AOPP-Human Serum Albumin (AOPP-HSA) native protein
• Provided at 7.5 mg/mL
Oxidative stress is defined as an increase in the production of reactive oxygen species (ROS) due to an imbalance between antioxidant and oxidants. Advanced Oxidation Protein Products (AOPP) are uremic toxins created during oxidative stress through the reaction of chlorinated oxidants, such as chloramines and hypochlorous acid, with plasma proteins. AOPPs are structurally similar to Advanced Glycation End-Product (AGE) proteins and exert similar biological activities. AOPPs are elevated in patients with renal complications, atherosclerosis, diabetes mellitus, systemic sclerosis, as well as HIV-positive patients. Human Serum Albumin (HSA) treated with HOCl and AOPP generated in vivo can ignite oxidative reactions in both neutrophils and monocytes, which indicates both can be used as true mediators of inflammation. Although the mechanisms of AOPP degradation and elimination from the blood remain to be fully elucidated, it appears that the liver and spleen are mostly responsible for their isolation and removal.
Oxidative stress is defined as an increase in the production of reactive oxygen species (ROS) due to an imbalance between antioxidant and oxidants. Advanced Oxidation Protein Products (AOPP) are uremic toxins created during oxidative stress through the reaction of chlorinated oxidants, such as chloramines and hypochlorous acid, with plasma proteins. AOPPs are structurally similar to Advanced Glycation End-Product (AGE) proteins and exert similar biological activities. AOPPs are elevated in patients with renal complications, atherosclerosis, diabetes mellitus, systemic sclerosis, as well as HIV-positive patients. Human Serum Albumin (HSA) treated with HOCl and AOPP generated in vivo can ignite oxidative reactions in both neutrophils and monocytes, which indicates both can be used as true mediators of inflammation. Although the mechanisms of AOPP degradation and elimination from the blood remain to be fully elucidated, it appears that the liver and spleen are mostly responsible for their isolation and removal.
Product Categories/Family for AOPP-Human Serum Albumin (AOPP-HSA) native protein
References
1. Deschamps-Latscha B. et al. (2005) Am. J. Kidney Dis. 45(1): 39-47.
2. Servettaz, A. et al. (2007) Ann. Rheum. Dis. 66: 1202-1209.
3. Witko-Sarsat, V. et al. (1996) Kidney International 49: 1304-1313.
2. Servettaz, A. et al. (2007) Ann. Rheum. Dis. 66: 1202-1209.
3. Witko-Sarsat, V. et al. (1996) Kidney International 49: 1304-1313.
Similar Products
Product Notes
The AOPP-Human Serum Albumin (AOPP-HSA) (Catalog #AAA169060) is a Native Protein and is intended for research purposes only. The product is available for immediate purchase. AOPP-HSA Conjugate is a simple, reproducible, and consistent control for assays measuring the detection of advanced oxidation protein products in plasma, lysates, and tissue homogenates. The AOPP-HSA concentration was determined from a Chloramine equivalence standard. Researchers should empirically determine the suitability of the AOPP-Human Serum Albumin (AOPP-HSA) for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "AOPP-Human Serum Albumin (AOPP-HSA), Native Protein" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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