Western Blot (WB)
(GSC Antibody (N-term) western blot analysis in mouse stomach tissue lysates (35ug/lane).This demonstrates the GSC antibody detected the GSC protein (arrow).)
Rabbit anti-Mouse GSC Polyclonal Antibody | anti-GSC antibody
GSC Antibody (N-term)
Western Blot (WB)
(GSC Antibody (N-term) western blot analysis in mouse stomach tissue lysates (35ug/lane).This demonstrates the GSC antibody detected the GSC protein (arrow).)
Western Blot (WB)
(GSC Antibody (N-term) western blot analysis in mouse stomach tissue lysates (35ug/lane).This demonstrates the GSC antibody detected the GSC protein (arrow).)
paired (PRD) homeobox family of proteins. The encoded protein acts
as a transcription factor and may be autoregulatory. A similar
protein in mice plays a role in craniofacial and rib cage
development during embryogenesis.
Paterson, A.D., et al. Diabetes 59(2):539-549(2010)
Zhang, Q.G., et al. Plast. Reconstr. Surg. 124(4):1157-1164(2009)
Schlade-Bartusiak, K., et al. Am. J. Med. Genet. A 146A (1), 117-123 (2008) :
Hartwell, K.A., et al. Proc. Natl. Acad. Sci. U.S.A. 103(50):18969-18974(2006)
NCBI and Uniprot Product Information
NCBI Description
This gene encodes a member of the bicoid subfamily of the paired (PRD) homeobox family of proteins. The encoded protein acts as a transcription factor and may be autoregulatory. A similar protein in mice plays a role in craniofacial and rib cage development during embryogenesis. [provided by RefSeq, Jul 2008]
Uniprot Description
GSC: Regulates chordin (CHRD). May play a role in spatial programing within discrete embryonic fields or lineage compartments during organogenesis. In concert with NKX3-2, plays a role in defining the structural components of the middle ear; required for the development of the entire tympanic ring. Belongs to the paired homeobox family. Bicoid subfamily.
Protein type: DNA-binding; Transcription factor
Chromosomal Location of Human Ortholog: 14q32.1
Cellular Component: transcription factor complex; nucleus
Molecular Function: sequence-specific DNA binding
Biological Process: neural crest cell fate specification; negative regulation of Wnt receptor signaling pathway; forebrain development; gastrulation; negative regulation of transcription from RNA polymerase II promoter; middle ear morphogenesis; muscle morphogenesis; dorsoventral neural tube patterning; embryonic skeletal morphogenesis
Disease: Short Stature, Auditory Canal Atresia, Mandibular Hypoplasia, And Skeletal Abnormalities
Research Articles on GSC
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Product Notes
The GSC gsc (Catalog #AAA9202702) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The immunogen sequence is 38-65. The GSC Antibody (N-term) reacts with Mouse and may cross-react with other species as described in the data sheet. AAA Biotech's GSC can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB), ELISA (EIA). WB~~1:1000. Researchers should empirically determine the suitability of the GSC gsc for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "GSC, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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