Structure
ZSTK-474, Inhibitor
ZSTK-474
Purity
>98% (HPLC)
Synonyms
ZSTK-474; ZSTK474; ZSTK 474; inhibitor
Purity/Purification
>98% (HPLC)
Suitability
10mM in DMSO
Target
PI3K
Receptor
PI3K; PI3Kalpha; PI3Kbeta; PI3Kgamma; PI3Kdelta
Chemical Name
1H-Benzimidazole, 2-(difluoromethyl)-1-(4, 6-di-4-morpholinyl-1, 3, 5-triazin-2-yl)
SMILES
FC(C1=NC2=CC=CC=C2N1C3=NC(N4CCOCC4)=NC(N5CCOCC5)=N3)F
Molecular Formula
C19H21F2N7O2
CAS Number
475110-96-4
Preparation and Storage
Store at -20 degree C
Stability: >=2 years
Shipping: Ice Pack
Stability: >=2 years
Shipping: Ice Pack
Structure
Structure
Related Product Information for ZSTK-474, inhibitor
A potent inhibitor of class I PI3K isoforms with IC50 of 17nM, 53nM, and 6nM for p110beta, p110gamma, and p110delta, respectively; shows potent antiproliferative activity against a panel of 39 human cancer cell lines with mean GI50 of 0.32uM, more effectively than that of LY294002 or wortmannin; induces apoptosis in OVCAR3 cells, and induces complete G1-phase arrest but not apoptosis in A549 cells at 10uM; completely inhibits the growth of A549, PC-3, and WiDr xenografts in mice at 400mg/kg; and induces the regression of A549 xenograft tumors. Solid Tumors Phase 1 Clinical
Product Categories/Family for ZSTK-474, inhibitor
References
1. Yaguchi S, et al. J Natl Cancer Inst, 2006, 98 (8), 545-556.
2. Kong D, et al. Cancer Sci, 2007, 98 (10), 1638-1642.
3. Kong D, et al. Eur J Cancer, 2009, 45 (5), 857-865.
2. Kong D, et al. Cancer Sci, 2007, 98 (10), 1638-1642.
3. Kong D, et al. Eur J Cancer, 2009, 45 (5), 857-865.
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Product Notes
The ZSTK-474 (Catalog #AAA3604578) is an Inhibitor and is intended for research purposes only. The product is available for immediate purchase. It is sometimes possible for the material contained within the vial of "ZSTK-474, Inhibitor" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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