Structure
GDC-0084, Inhibitor
GDC-0084
Purity
>98% (HPLC)
Synonyms
GDC-0084; RG-7666; inhibitor
Purity/Purification
>98% (HPLC)
Suitability
DMSO: 6mg/mL (Need ultrasonic)
Target
PI3K
Receptor
mTOR; PI3Kalpha; PI3Kbeta; PI3Kgamma; PI3Kdelta
Chemical Name
2-Pyrimidinamine, 5-[8, 9-dihydro-6, 6-dimethyl-4-(4-morpholinyl)-6H-[1, 4]oxazino[4, 3-e]purin-2-yl]
SMILES
NC1=NC=C(C2=NC(N3CCOCC3)=C4N=C(C(C)(C)OCC5)N5C4=N2)C=N1
Molecular Formula
C18H22N8O2
CAS Number
1382979-44-3
Preparation and Storage
Store at -20 degree C
Stability: >=2 years
Shipping: Ice Pack
Stability: >=2 years
Shipping: Ice Pack
Structure
Structure
Related Product Information for GDC-0084, inhibitor
A potent, selective, brain penetrant dual inhibitor of class I PI3Ks and mTOR with Ki of 2/46/3/10/70nM for PI3Kalpha/beta/delta/gamma/mTOR, respectively; highly selective against a panel of 229 kinases (IC50>1uM); shows antiproliferative (EC50 =0.3-1.1uM) in 5 GBM cell lines; significantly and dose-dependently inhibits tumor growth in a subcutaneous U87 tumor xenograft model of glioblastoma in mice. Brain Cancer Phase 2 Discontinued
Product Categories/Family for GDC-0084, inhibitor
References
1. Heffron TP, et al. ACS Med Chem Lett. 2016 Feb 16; 7 (4):351-6.
2. Salphati L, et al. Drug Metab Dispos. 2016 Dec; 44 (12):1881-1889.
2. Salphati L, et al. Drug Metab Dispos. 2016 Dec; 44 (12):1881-1889.
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Product Notes
The GDC-0084 (Catalog #AAA3601585) is an Inhibitor and is intended for research purposes only. The product is available for immediate purchase. It is sometimes possible for the material contained within the vial of "GDC-0084, Inhibitor" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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