Structure
PIK-90, Inhibitor
PIK-90
Purity
>98% (HPLC)
Synonyms
PIK-90; PIK90; PIK 90; inhibitor
Purity/Purification
>98% (HPLC)
Suitability
DMSO: <1mg/mL
Target
PI3K
Receptor
PI3Kalpha; PI3Kbeta; PI3Kgamma; PI3Kdelta
Chemical Name
3-Pyridinecarboxamide, N-(2, 3-dihydro-7, 8-dimethoxyimidazo[1, 2-c]quinazolin-5-yl)
SMILES
O=C(NC1=NC2=C(C=CC(OC)=C2OC)C3=NCCN13)C4=CN=CC=C4
Molecular Formula
C18H17N5O3
CAS Number
677338-12-4
Preparation and Storage
Store at -20 degree C
Stability: >=2 years
Shipping: Ice Pack
Stability: >=2 years
Shipping: Ice Pack
Structure
Structure
Related Product Information for PIK-90, inhibitor
PIK-90 is a potent DNA-PK and PI3K inhibitor that inhibits p110alpha, p110gamma and DNA-PK with IC50s of 11, 18 and 13nM, respectively; inhibits phosphorylation of Akt and S6, blocks the antiapoptotic protein Survivin and driving cell death in malignant glioma the clinical CDK1/2 inhibitor cooperated with roscovitine.
Product Categories/Family for PIK-90, inhibitor
References
1. Fan QW, et al. Cancer Res. 2007 Sep 1; 67 (17):7960-5.
2. Niedermeier M, et al. Blood. 2009 May 28; 113 (22):5549-57.
3. Knight ZA, et al. Cell. 2006 May 19; 125 (4):733-47.
4. Cheng CK, et al. Proc Natl Acad Sci U S A. 2012 Jul 31; 109 (31):12722-7.
2. Niedermeier M, et al. Blood. 2009 May 28; 113 (22):5549-57.
3. Knight ZA, et al. Cell. 2006 May 19; 125 (4):733-47.
4. Cheng CK, et al. Proc Natl Acad Sci U S A. 2012 Jul 31; 109 (31):12722-7.
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Product Notes
The PIK-90 (Catalog #AAA3605587) is an Inhibitor and is intended for research purposes only. The product is available for immediate purchase. It is sometimes possible for the material contained within the vial of "PIK-90, Inhibitor" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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