Structure
AZD8835, Inhibitor
AZD8835
Purity
>98% (HPLC)
Synonyms
AZD8835; AZD-8835; inhibitor
Purity/Purification
>98% (HPLC)
Suitability
DMSO: 16mg/mL
Target
PI3K
Receptor
PI3Kalpha; PI3Kbeta; PI3Kgamma; PI3Kdelta
Chemical Name
1-Propanone, 1-[4-[5-[5-amino-6-[5-(1, 1-dimethylethyl)-1, 3, 4-oxadiazol-2-yl]-2-pyrazinyl]-1-ethyl-1H-1, 2, 4-triazol-3-yl]-1-piperidinyl]-3-hydroxy
SMILES
O=C(N1CCC(C2=NN(CC)C(C3=NC(C4=NN=C(C(C)(C)C)O4)=C(N)N=C3)=N2)CC1)CCO
Molecular Formula
C22H31N9O3
CAS Number
1620576-64-8
Preparation and Storage
Store at -20 degree C
Stability: >=2 years
Shipping: Ice Pack
Stability: >=2 years
Shipping: Ice Pack
Structure
Structure
Related Product Information for AZD8835, inhibitor
AZD8835 (AZD-8835) is a potent, selective inhibitor of PI3Kalpha and PI3Kdelta with IC50 of 6.2 and 5.7nM, 15-fold and >100-fold selectivity over PI3Kgamma and PI3Kbeta; also potently inhibits PI3Kalpha mutants E545K and H1047R with IC50 of 6nM; preferentially inhibits growth in cells with mutant PIK3CA status inhibits AKT phosphorylation with IC50 of 58nM in PIK3CA mutant human breast ductal carcinoma BT474 cell line; suppresses tumour growth (93% tumour growth inhibition) in murine H1047R PI3Kalpha mutated SKOV-3 xenograft tumour model (25mg/kg b. I. D). Breast Cancer Phase 1 Discontinued
Product Categories/Family for AZD8835, inhibitor
References
1. Barlaam B, et al. Bioorg Med Chem Lett. 2015 Nov 15; 25 (22):5155-62.
2. Hudson K, et al. Mol Cancer Ther. 2016 May; 15 (5):877-89.
3. Lynch JT, et al. Oncotarget. 2016 Apr 19; 7 (16):22128-39.
4. Maynard J, et al. PLoS One. 2017 Aug 14; 12 (8):e0183048.
2. Hudson K, et al. Mol Cancer Ther. 2016 May; 15 (5):877-89.
3. Lynch JT, et al. Oncotarget. 2016 Apr 19; 7 (16):22128-39.
4. Maynard J, et al. PLoS One. 2017 Aug 14; 12 (8):e0183048.
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Product Notes
The AZD8835 (Catalog #AAA3602383) is an Inhibitor and is intended for research purposes only. The product is available for immediate purchase. It is sometimes possible for the material contained within the vial of "AZD8835, Inhibitor" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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