Structure
TG100-115, Inhibitor
TG100-115
Purity
>98% (HPLC)
Synonyms
TG100-115; TG100115; TG100 115; inhibitor
Purity/Purification
>98% (HPLC)
Suitability
10mM in DMSO
Target
PI3K
Receptor
PI3Kalpha; PI3Kbeta; PI3Kgamma; PI3Kdelta
Chemical Name
Phenol, 3, 3'-(2, 4-diamino-6, 7-pteridinediyl)bis
SMILES
OC1=CC=CC(C2=NC3=NC(N)=NC(N)=C3N=C2C4=CC=CC(O)=C4)=C1
Molecular Formula
C18H14N6O2
CAS Number
677297-51-7
Preparation and Storage
Store at -20 degree C
Stability: >=2 years
Shipping: Ice Pack
Stability: >=2 years
Shipping: Ice Pack
Structure
Structure
Related Product Information for TG100-115, inhibitor
A potent, selective PI3Kgamma/delta with IC50 of 83/235nM, respectively; shows no significant inhibitory activity against pI3Kalpha and beta, and a broad panel of kinases (IC50>1uM); potently inhibits edema and inflammation in response to multiple mediators known to participate in myocardial infarction, such as VEGF and platelet-activating factor, without effect on endothelial cell mitogenesis; provides potent cardioprotection, reduces infarct development and preserves myocardial function in animal MI models. COPD Discontinued
Product Categories/Family for TG100-115, inhibitor
References
1. Doukas J, et al. Proc Natl Acad Sci U S A. 2006 Dec 26; 103 (52):19866-71.
2. Doukas J, et al. J Pharmacol Exp Ther. 2009 Mar; 328 (3):758-65.
3. Kaneda MM, et al. Cancer Discov. 2016 Aug; 6 (8):870-85.
2. Doukas J, et al. J Pharmacol Exp Ther. 2009 Mar; 328 (3):758-65.
3. Kaneda MM, et al. Cancer Discov. 2016 Aug; 6 (8):870-85.
Similar Products
Product Notes
The TG100-115 (Catalog #AAA3605585) is an Inhibitor and is intended for research purposes only. The product is available for immediate purchase. It is sometimes possible for the material contained within the vial of "TG100-115, Inhibitor" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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