Structure
Voxtalisib, Inhibitor
Voxtalisib
Purity
>98% (HPLC)
Synonyms
Voxtalisib; XL765; SAR245409; SAR-245409; XL 765; XL-765; inhibitor
Purity/Purification
>98% (HPLC)
Suitability
DMSO: 16mg/mL
Target
PI3K
Receptor
DNA-PK; PI3Kalpha; PI3Kbeta; PI3Kgamma; PI3Kdelta
Chemical Name
Pyrido[2, 3-d]pyrimidin-7(8H)-one, 2-amino-8-ethyl-4-methyl-6-(1H-pyrazol-3-yl)
SMILES
O=C1C(C2=CC=NN2)=CC3=C(C)N=C(N)N=C3N1CC
Molecular Formula
C13H14N6O
CAS Number
934493-76-2
Preparation and Storage
Store at -20 degree C
Stability: >=2 years
Shipping: Ice Pack
Stability: >=2 years
Shipping: Ice Pack
Structure
Structure
Related Product Information for Voxtalisib, inhibitor
A potent, highly selective ATP-competitive inhibitor of class I PI3Ks with IC50s of 39/110/43/9nM for p110alpha/p110beta/p110delta/p120gamma; also inhibits mTORC1/mTORC2/DNA-PK (IC50=160/910/150nM) and shows weak inhibitory activity toward VPS34 (IC50=9.1uM); inhibits phosphorylation of AKT, p70S6K, and S6 phosphorylation in multiple tumor cell lines; orally bioactive in mouse xenograft models. Solid Tumors Phase 2 Clinical
Product Categories/Family for Voxtalisib, inhibitor
References
1. Yu P, et al. Mol Cancer Ther. 2014 May; 13 (5):1078-91.
2. Papadopoulos KP, et al. Clin Cancer Res. 2014 May 1; 20 (9):2445-56.
3. Thijssen R, et al. Leukemia. 2016 Feb; 30 (2):337-45.
2. Papadopoulos KP, et al. Clin Cancer Res. 2014 May 1; 20 (9):2445-56.
3. Thijssen R, et al. Leukemia. 2016 Feb; 30 (2):337-45.
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Product Notes
The Voxtalisib (Catalog #AAA3606674) is an Inhibitor and is intended for research purposes only. The product is available for immediate purchase. It is sometimes possible for the material contained within the vial of "Voxtalisib, Inhibitor" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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