Structure
AZD-8055, Inhibitor
AZD-8055
Purity
>98% (HPLC)
Synonyms
AZD-8055; AZD8055; AZD 8055; inhibitor
Purity/Purification
>98% (HPLC)
Suitability
10mM in DMSO
Target
mTOR
Receptor
DNA-PK; mTOR (fulllength); mTOR (truncated); PI3Kalpha; PI3Kdelta; mTOR
Chemical Name
Benzenemethanol, 5-[2, 4-bis[(3S)-3-methyl-4-morpholinyl]pyrido[2, 3-d]pyrimidin-7-yl]-2-methoxy
SMILES
OCC1=CC(C2=NC3=NC(N4[C@@H](C)COCC4)=NC(N5[C@@H](C)COCC5)=C3C=C2)=CC=C1OC
Molecular Formula
C25H31N5O4
CAS Number
1009298-09-2
Preparation and Storage
Store at -20 degree C
Stability: >=2 years
Shipping: Ice Pack
Stability: >=2 years
Shipping: Ice Pack
Structure
Structure
Related Product Information for AZD-8055, inhibitor
A potent, selective, ATP-competitive and orally bioavailable mTOR inhibitor with IC50 of 0.8nM; shows excellent selectivity (1,000-fold) against all class I PI3K isoforms and other PI3K-like kinases; inhibits the phosphorylation of mTORC1 substrates p70S6K and 4E-BP1, and phosphorylation of the mTORC2 substrate AKT and downstream proteins, also fully inhibits rapamycin-resistant T37/46 phosphorylation sites on 4E-BP1; potently inhibits proliferation and induces autophagy in H838 and A549 cells; exhibits tumor growth inhibition in vivo. Solid Tumors Phase 2 Discontinued
Product Categories/Family for AZD-8055, inhibitor
References
1. Chresta CM, et al. Cancer Res. 2010 Jan 1; 70 (1):288-98.
2. Sini P, et al. Autophagy. 2010 May; 6 (4):553-4.
3. Jiang Q, et al. Cancer Res. 2011 Jun 15; 71 (12):4074-84.
4. Willems L, et al. Leukemia. 2012 Jun; 26 (6):1195-202.
2. Sini P, et al. Autophagy. 2010 May; 6 (4):553-4.
3. Jiang Q, et al. Cancer Res. 2011 Jun 15; 71 (12):4074-84.
4. Willems L, et al. Leukemia. 2012 Jun; 26 (6):1195-202.
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Product Notes
The AZD-8055 (Catalog #AAA3600061) is an Inhibitor and is intended for research purposes only. The product is available for immediate purchase. It is sometimes possible for the material contained within the vial of "AZD-8055, Inhibitor" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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