Structure
Torin1, Inhibitor
Torin1
Purity
>98% (HPLC)
Synonyms
Torin1; Torin 1; Torin-1; inhibitor
Purity/Purification
>98% (HPLC)
Suitability
DMSO: 6.6mg/mL (Need ultrasonic or warming)
Target
mTOR
Receptor
DNA-PK; mTOR; mTORC1; mTORC2; p110gamma
Chemical Name
Benzo[h]-1, 6-naphthyridin-2(1H)-one, 1-[4-[4-(1-oxopropyl)-1-piperazinyl]-3-(trifluoromethyl)phenyl]-9-(3-quinolinyl)
SMILES
O=C1N(C2=CC=C(N3CCN(C(CC)=O)CC3)C(C(F)(F)F)=C2)C4=C(C=NC5=CC=C(C6=CC7=CC=CC=C7N=C6)C=C54)C=C1
Molecular Formula
C35H28F3N5O2
CAS Number
1222998-36-8
Preparation and Storage
Store at -20 degree C
Stability: >=2 years
Shipping: Ice Pack
Stability: >=2 years
Shipping: Ice Pack
Structure
Structure
Related Product Information for Torin1, inhibitor
Torin1 is a highly potent, selective inhibitor of mTORC1 and mTORC2 with IC50 of 2 and 10nM in cell-free assays, exhibits 1,000-fold selectivity PI3K (EC50=1, 800nM); exhibits 100-fold binding selectivity relative to 450 other protein kinases; causes cell cycle arrest through a rapamycin-resistant mechanism that is also independent of mTORC2, disrupts mTORC1-dependent phenotypes more completely than rapamycin; prevents the anti-inflammatory potency of GC both in human monocytes and myeloid dendritic cells.
Product Categories/Family for Torin1, inhibitor
References
1. Thoreen CC, et al. J Biol Chem. 2009 Mar 20; 284 (12):8023-32.
2. Liu Q, et al. J Med Chem. 2010 Oct 14; 53 (19):7146-55.
3. Weichhart T, et al. Blood. 2011 Apr 21; 117 (16):4273-83.
4. Thoreen CC, et al. Autophagy. 2009 Jul; 5 (5):725-6.
2. Liu Q, et al. J Med Chem. 2010 Oct 14; 53 (19):7146-55.
3. Weichhart T, et al. Blood. 2011 Apr 21; 117 (16):4273-83.
4. Thoreen CC, et al. Autophagy. 2009 Jul; 5 (5):725-6.
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Product Notes
The Torin1 (Catalog #AAA3600848) is an Inhibitor and is intended for research purposes only. The product is available for immediate purchase. It is sometimes possible for the material contained within the vial of "Torin1, Inhibitor" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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