Structure
OSI-027, Inhibitor
OSI-027
Purity
>98% (HPLC)
Synonyms
OSI-027; OSI027; OSI 027; inhibitor
Purity/Purification
>98% (HPLC)
Suitability
10mM in DMSO
Target
mTOR
Receptor
DNA-PK; mTOR; mTORC1; mTORC2; PI3Kgamma
Chemical Name
Cyclohexanecarboxylic acid, 4-[4-amino-5-(7-methoxy-1H-indol-2-yl)imidazo[5, 1-f][1, 2, 4]triazin-7-yl]-, trans
SMILES
COC1=CC=CC2=C1NC(=C2)C1=C2N(N=CN=C2N)C(=N1)[C@H]1CC[C@@H](CC1)C(O)=O|r,c:4,6,10,16,18,22,t:2,13|
Molecular Formula
C21H22N6O3
CAS Number
936890-98-1
Preparation and Storage
Store at -20 degree C
Stability: >=2 years
Shipping: Ice Pack
Stability: >=2 years
Shipping: Ice Pack
Structure
Structure
Related Product Information for OSI-027, inhibitor
A potent and selective inhibitor of mTORC1 and mTORC2 with IC50 of 22nM and 65nM, respectively; displays >100-fold selectivity for mTOR over PI3Kalpha, PI3Kbeta, PI3Kgamma, and DNA-PK; inhibits phosphorylation of the mTORC1 substrates 4E-BP1 and S6K1 as well as the mTORC2 substrate AKT in diverse cancer models in vitro and in vivo; demonstrates robust antitumor activity in human xenograft models. Blood Cancer Phase 1 Discontinued
Product Categories/Family for OSI-027, inhibitor
References
1. Carayol N, et al. Proc Natl Acad Sci U S A. 2010 Jul 13; 107 (28):12469-74.
2. Falcon BL, et al. Cancer Res. 2011 Mar 1; 71 (5):1573-83.
3. Altman JK, et al. Clin Cancer Res. 2011 Jul 1; 17 (13):4378-88.
4. Bhagwat SV, et al. Mol Cancer Ther. 2011 Aug; 10 (8):1394-406.
2. Falcon BL, et al. Cancer Res. 2011 Mar 1; 71 (5):1573-83.
3. Altman JK, et al. Clin Cancer Res. 2011 Jul 1; 17 (13):4378-88.
4. Bhagwat SV, et al. Mol Cancer Ther. 2011 Aug; 10 (8):1394-406.
Similar Products
Product Notes
The OSI-027 (Catalog #AAA3606705) is an Inhibitor and is intended for research purposes only. The product is available for immediate purchase. It is sometimes possible for the material contained within the vial of "OSI-027, Inhibitor" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
If you are ready to order, navigate to Shopping Cart and get ready to checkout.
