Structure
LY3023414, Inhibitor
LY3023414
Purity
>98% (HPLC)
Synonyms
LY3023414; LY-3023414; LY 3023414; inhibitor
Purity/Purification
>98% (HPLC)
Suitability
10mM in DMSO
Target
PI3K
Receptor
classIPI3Kisoforms; DNA-PK; mTORkinase
Chemical Name
2H-Imidazo[4, 5-c]quinolin-2-one, 1, 3-dihydro-8-[5-(1-hydroxy-1-methylethyl)-3-pyridinyl]-1-[(2S)-2-methoxypropyl]-3-methyl
SMILES
O=C(N1C[C@@H](OC)C)N(C)C2=C1C3=CC(C4=CC(C(C)(O)C)=CN=C4)=CC=C3N=C2
Molecular Formula
C23H26N4O3
CAS Number
1386874-06-1
Preparation and Storage
Store at -20 degree C
Stability: >=2 years
Shipping: Ice Pack
Stability: >=2 years
Shipping: Ice Pack
Structure
Structure
Related Product Information for LY3023414, inhibitor
LY3023414 is a potent, dual PI3K/mTOR inhibitor with IC50 of 6.07nM, 77.6nM, 38nM, 23.8nM, 165nM and 4.24nM for PI3Kalpha, PI3Kbeta, PI3Kdelta, PI3Kgamma, mTOR and DNA-PK, respectively; inhibits the phosphorylation of AKT at position T308 with IC50 of 106nM in the PTEN-deficient U87mg glioblastoma cell line, inhibits phosphorylation of AKT at position S473 (IC50=94.2nM) by mTORC2 as well as phosphorylation of mTORC1 kinase targets p70S6K (position T389; IC50=10.6nM); causes G1 cell-cycle arrest and shows broad antiproliferative activity in cancer cell panel screens; exhibits antitumor activity in multiple xenograft models. Lung Cancer Phase 2 Clinical
Product Categories/Family for LY3023414, inhibitor
References
1. Smith MC, et al. Mol Cancer Ther. 2016 Oct; 15 (10):2344-2356.
2. Zaidi AH, et al. Ann Surg. 2017 Jul; 266 (1):91-98.
3. Wei L, et al. Oncotarget. 2016 Nov 22; 7 (47):76374-76389.
4. Zheng L, et al. Oncotarget. 2017 Oct 27; 8 (58):98964-98973.
2. Zaidi AH, et al. Ann Surg. 2017 Jul; 266 (1):91-98.
3. Wei L, et al. Oncotarget. 2016 Nov 22; 7 (47):76374-76389.
4. Zheng L, et al. Oncotarget. 2017 Oct 27; 8 (58):98964-98973.
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Product Notes
The LY3023414 (Catalog #AAA3601608) is an Inhibitor and is intended for research purposes only. The product is available for immediate purchase. It is sometimes possible for the material contained within the vial of "LY3023414, Inhibitor" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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