Structure
IC-87114 Biochemical
IC-87114
Purity
>98% (HPLC)
Synonyms
IC-87114; IC87114; IC 87114; IC-87114 biochemical
Purity/Purification
>98% (HPLC)
Suitability
10mM in DMSO
Target
PI3K
Receptor
PI3Kbeta; PI3Kgamma; PI3Kdelta
Chemical Name
4(3H)-Quinazolinone, 2-[(6-amino-9H-purin-9-yl)methyl]-5-methyl-3-(2-methylphenyl)
SMILES
O=C1N(C2=CC=CC=C2C)C(CN3C=NC4=C(N)N=CN=C34)=NC5=C1C(C)=CC=C5
Molecular Formula
C22H19N7O
CAS Number
371242-69-2
Preparation and Storage
Store at -20 degree C
Stability: >=2 years
Shipping: Ice Pack
Stability: >=2 years
Shipping: Ice Pack
Structure
Structure
Related Product Information for IC-87114 biochemical
A potent and selective PI3Kdelta inhibitor with IC50 of 0.5uM; displays 58-fold selectivity over PI3Kgamma, and >100-fold over PI3Kalpha and PI3Kbeta; inhibits polarized morphology of neutrophils, fMLP-stimulated PIP3 production and chemotaxis; inhibits constitutive phosphorylation of Akt/PKB and suppresses AML cell proliferation; reduces vascular permeability in a murine model of asthma.
Product Categories/Family for IC-87114 biochemical
References
1. Sadhu C, et al. J Immunol. 2003 Mar 1; 170 (5):2647-54.
2. Billottet C, et al. Oncogene. 2006 Oct 26; 25 (50):6648-59.
3. Puri KD, et al. Blood. 2004 May 1; 103 (9):3448-56.
4. Lee KS, et al. J Allergy Clin Immunol. 2006 Aug; 118 (2):403-9.
2. Billottet C, et al. Oncogene. 2006 Oct 26; 25 (50):6648-59.
3. Puri KD, et al. Blood. 2004 May 1; 103 (9):3448-56.
4. Lee KS, et al. J Allergy Clin Immunol. 2006 Aug; 118 (2):403-9.
Similar Products
Product Notes
The IC-87114 (Catalog #AAA3604278) is a Biochemical and is intended for research purposes only. The product is available for immediate purchase. It is sometimes possible for the material contained within the vial of "IC-87114, Biochemical" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
If you are ready to order, navigate to Shopping Cart and get ready to checkout.
