Structure
Torin2, Inhibitor
Torin2
Purity
>98% (HPLC)
Synonyms
Torin2; Torin 2; Torin-2; inhibitor
Purity/Purification
>98% (HPLC)
Suitability
10mM in DMSO
Target
mTOR
Receptor
ATM; ATR; DNA-PK; mTOR
Chemical Name
Benzo[h]-1, 6-naphthyridin-2(1H)-one, 9-(6-amino-3-pyridinyl)-1-[3-(trifluoromethyl)phenyl]
SMILES
O=C1N(C2=CC=CC(C(F)(F)F)=C2)C3=C(C=NC4=CC=C(C5=CC=C(N)N=C5)C=C43)C=C1
Molecular Formula
C24H15F3N4O
CAS Number
1223001-51-1
Preparation and Storage
Store at -20 degree C
Stability: >=2 years
Shipping: Ice Pack
Stability: >=2 years
Shipping: Ice Pack
Structure
Structure
Related Product Information for Torin2, inhibitor
Torin2 is a potent, selective, orally available inhibitor of mTOR, inhibits mTORC1-dependent T389 phosphorylation on S6K with IC50 of 0.25nM, exhibits 800-fold selectivity over PI3K, and >100-fold over 440 other protein kinases; also exhibits potent biochemical and cellular activity against PIKK family kinases including ATM (EC50=28nM), ATR (EC50=35nM), and DNA-PK (EC50=118nM); inhibits mTOR kinase and mTORC1 signaling activities, results in a prolonged block in negative feedback and consequent T308 phosphorylation on Akt in treated cancer cells; demonstrates significant growth inhibition against KRAS-driven lung tumors combined with MEK inhibitor AZD6244, does not yield significant efficacy as a single agent; overcomes the resistance of ALK (F1174L)/MYCN tumors to crizotinib in vivo.
Product Categories/Family for Torin2, inhibitor
References
1. Liu Q, et al. J Med Chem. 2011 Mar 10; 54 (5):1473-80.
2. Liu Q, et al. Cancer Res. 2013 Apr 15; 73 (8):2574-86.
3. Berry T, et al. Cancer Cell. 2012 Jul 10; 22 (1):117-30.
2. Liu Q, et al. Cancer Res. 2013 Apr 15; 73 (8):2574-86.
3. Berry T, et al. Cancer Cell. 2012 Jul 10; 22 (1):117-30.
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Product Notes
The Torin2 (Catalog #AAA3600851) is an Inhibitor and is intended for research purposes only. The product is available for immediate purchase. It is sometimes possible for the material contained within the vial of "Torin2, Inhibitor" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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